Cytokeratin 19 Antibody (AF488) (YA6147)

Cat. No.: HY-P89398M: Data Sheet User Guide for Antibodies
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Cytokeratin 19 Antibody (YA6147) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 19.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Cytokeratin 19 Antibody (YA6147) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 19.

Host

Rabbit

Clonality

Monoclonal,Recombinant

Molecular Weight

Predicted band size: 44 kDa;

Observed band size: 44 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

P08727

Gene ID

3880 [NCBI]

Immunogen

Synthetic peptide within Human Cytokeratin 19 aa 348-400.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100
IF-Tissue IF-Tissue: Immunofluorescence-Tissue	1:100
FC FC: Flow Cytometry	1ug/mL

Purity	Protein A	Modification	Unmodified
Isotype	IgG

Appearance

Solution

Formulation

Supplied in Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4; Not functional in the nucleotide excision repair pathway; Not functional in the nucleotide excision repair pathway; Not functional in the nucleotide excision repair pathway

Subcellular Localization：Nucleus; Cytoplasm; Nucleus; Nucleus; Nucleus

Isoforms & Post-Translational Modification：P07992 has 4 isomers: P07992-1: 32562 Da (predicted); P07992-2: 29993 Da (predicted); P07992-3: 35563 Da (predicted); P07992-4: 25211 Da (predicted).
Ubiquitinated with both 'Lys-48' and 'Lys-63' linkages (PubMed:25538220). Deubiquitinated by USP45 (PubMed:25538220)

Subunit：Heterodimer composed of ERCC1 isoform 1 and ERCC4/XPF (PubMed:16076955, PubMed:16338413, PubMed:24036546, PubMed:25538220, PubMed:32034146). Interacts with USP45 (PubMed:25538220)

Synonyms

KRT19; Keratin, type I cytoskeletal 19; Cytokeratin-19; CK-19; Keratin-19; K19

Documentation

User Guide for Antibodies (1077 KB)