DTNB (Dystrobrevin beta) Antibody (YA8321)(PBS only)

Cat. No.: HY-P88637A: Data Sheet User Guide for Antibodies
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DTNB (Dystrobrevin beta) Antibody (YA8321) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DTNB (Dystrobrevin beta).

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

DTNB (Dystrobrevin beta) Antibody (YA8321) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DTNB (Dystrobrevin beta).

Host

Mouse

Molecular Weight

Predicted band size: 63.6 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O60941

Immunogen

Full length human recombinant protein of human DTNB produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity). May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470). May be required for proper maturation and function of a subset of inhibitory synapses (By similarity)

Subcellular Localization：Cytoplasm,Postsynaptic density,Cell projection, dendrite,Basal cell membrane,Postsynapse,Nucleus

Expression：
Tissue_Specificity: Highly expressed in brain, kidney and pancreas
Induction: Post-transcriptionally repressed by microRNA miR-143 during neural differentiation

Isoforms & Post-Translational Modification：O60941 has 7 isomers: O60941-1: 71356 Da (predicted); O60941-2: 64603 Da (predicted); O60941-3: 64424 Da (predicted); O60941-4: 68061 Da (predicted); O60941-5: 63760 Da (predicted); O60941-6: 61538 Da (predicted); O60941-7: 69294 Da (predicted).
Phosphorylated by PKA

Subunit：Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2 (PubMed:10747910)

Synonyms

MGC17163; MGC57126

Documentation

User Guide for Antibodies (1077 KB)