GUK1 (Guanylate Kinase 1) Antibody (YA8140)(PBS only)

Cat. No.: HY-P88456A: Data Sheet User Guide for Antibodies
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GUK1 (Guanylate Kinase 1) Antibody (YA8140) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GUK1 (Guanylate Kinase 1).

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

GUK1 (Guanylate Kinase 1) Antibody (YA8140) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GUK1 (Guanylate Kinase 1).

Host

Mouse

Molecular Weight

Predicted band size: 21.5 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q16774

Immunogen

Full length human recombinant protein of human GUK1 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500
FC FC: Flow Cytometry	1:100

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG2b

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for converting prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664)

Subcellular Localization：Photoreceptor inner segment,Cytoplasm, cytosol,Mitochondrion

Expression：
Tissue_Specificity: Widely expressed

Isoforms & Post-Translational Modification：Q16774 has three isomers: Q16774-1: 21726 Da (predicted); Q16774-2: 23782 Da (predicted); Q16774-3: 26596 Da (predicted).

Subunit：Monomer (PubMed:31201273)

Synonyms

GMK

Documentation

User Guide for Antibodies (1077 KB)