2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. Ionotropic Glutamate Receptor 2 Antibody (YA4014)(PBS only)

Ionotropic Glutamate Receptor 2 Antibody (YA4014)(PBS only)

製品番号: HY-P84317A
User Guide for Antibodies Technical Support

Ionotropic Glutamate Receptor 2 Antibody (YA4014) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Ionotropic Glutamate Receptor 2.

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容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

Ionotropic Glutamate Receptor 2 Antibody (YA4014) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Ionotropic Glutamate Receptor 2.
Host

Mouse
分子量
Predicted band size: 99 kDa;
Observed band size: 99 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Purified recombinant fragment of human GRIA2 (AA: 35-175) expressed in E. Coli.
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:200-1:1000
FC
FC: Flow Cytometry
1:200-1:400
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:10000
純度 affinity purified. Conjugation Non-conjugated
Isotype IgG2b  
Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:20614889, PubMed:31300657, PubMed:8003671). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (PubMed:14687553). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium (PubMed:20614889, PubMed:8003671). The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (By similarity). Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity)
Subcellular Localization：Cell membrane; Multi-pass membrane protein; Postsynaptic cell membrane; Multi-pass membrane protein; Postsynaptic density membrane; Multi-pass membrane protein
Isoforms & Post-Translational Modification：P42262 has 4 isomers: P42262-1: 98821 Da (predicted); P42262-2: 98878 Da (predicted); P42262-3: 100594 Da (predicted); P42262-4: 93775 Da (predicted).
Palmitoylated. Depalmitoylated upon L-glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis;Ubiquitinated by RNF167, leading to its degradation;Phosphorylation at Tyr-876 is required for interaction with IQSEC1 and ARF6 activation, which in turn triggers AMPAR internalization for persistent synaptic depression;N-glycosylated
Subunit：Homotetramer or heterotetramer of pore-forming glutamate receptor subunits (PubMed:14687553, PubMed:19651138, PubMed:20614889, PubMed:21531559, PubMed:8003671).
Synonyms
GLUR2; GLURB; GluA2; HBGR2; GluR-K2
ドキュメンテーション
User Guide for Antibodies (1077 KB)

Ionotropic Glutamate Receptor 2 Antibody (YA4014)(PBS only) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
Ionotropic Glutamate Receptor 2 Antibody (YA4014)(PBS only)
製品番号:
HY-P84317A
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