kappa Opioid Receptor Antibody (YA3132)(PBS only)

Cat. No.: HY-P83387A: Data Sheet User Guide for Antibodies
FAQs
Technical Support

kappa Opioid Receptor Antibody (YA3132) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to kappa Opioid Receptor.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

kappa Opioid Receptor Antibody (YA3132) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to kappa Opioid Receptor.

Host

Rabbit

Molecular Weight

Predicted band size: 43 kDa;

Observed band size: 60 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Rat

SwissProt ID

P33534

Gene ID

18387 [NCBI]

Immunogen

A synthetic peptide of mouse Kappa Opioid Receptor

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IP IP: Immunoprecipitation	1:20

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions

Subcellular Localization：Cell membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Detected in brain (at protein level) . Brain (neocortex, hippocampus, amygdala, medial habenula, hypothalamus, locus ceruleus, and parabrachial nucleus)

Subunit：Interacts with NHERF1. Interacts with GABARAPL1 (By similarity)

Research Field

Neuroscience

Synonyms

KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1

Documentation

User Guide for Antibodies (1077 KB)