LDLRAP1 (ARH) Antibody (YA8055)(PBS only)

Cat. No.: HY-P88371A: Data Sheet User Guide for Antibodies
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LDLRAP1 (ARH) Antibody (YA8055) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LDLRAP1 (ARH).

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

LDLRAP1 (ARH) Antibody (YA8055) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LDLRAP1 (ARH).

Host

Mouse

Molecular Weight

Predicted band size: 33.7 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q5SW96

Immunogen

Full length human recombinant protein of human LDLRAP1 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity)

Subcellular Localization：Cytoplasm

Expression：
Tissue_Specificity: Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes

Isoforms & Post-Translational Modification：Q5SW96: 308 amino acids, molecular weight 33885 Da.

Subunit：Interacts (via PID domain) with LDLR (via NPXY motif) (PubMed:12221107)

Synonyms

ARH; ARH1; ARH2; FHCB1; FHCB2

Documentation

User Guide for Antibodies (1077 KB)