MASH1/Achaete-scute homolog 1 Antibody (YA7719)

Cat. No.: HY-P88034: Fiche technique User Guide for Antibodies
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MASH1/Achaete-scute homolog 1 Antibody (YA7719) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MASH1/Achaete-scute homolog 1.

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Size		Stock
50 μL		Obtenir un devis
100 μL		Obtenir un devis

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Description

Description

MASH1/Achaete-scute homolog 1 Antibody (YA7719) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MASH1/Achaete-scute homolog 1.

Host

Rabbit

Clonality

Recombinant

Masse moléculaire

Predicted band size: 26 kDa;

Predicted Reactivity

Human

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.

SwissProt ID

P50553

Immunogen

KLH conjugated synthetic peptide derived from human ASCL1

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1000

Sensitivity	Endogenous	Pureté	affinity purified by Protein A
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 10mM TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Livraison

Shipping with blue ice.

Background

Function：Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity)

Subcellular Localization：Nucleus

Isoforms & Post-Translational Modification：P50553: 236 amino acids, molecular weight 25454 Da.

Subunit：Efficient DNA binding requires dimerization with another bHLH protein

Documentation

User Guide for Antibodies (1077 KB)