Metabotropic Glutamate Receptor 2 Antibody (YA3218)(PBS only)

Cat. No.: HY-P83473A: Ficha de datos User Guide for Antibodies
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Metabotropic Glutamate Receptor 2 Antibody (YA3218) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Metabotropic Glutamate Receptor 2.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

Metabotropic Glutamate Receptor 2 Antibody (YA3218) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Metabotropic Glutamate Receptor 2.

Host

Rabbit

Peso molecular

Predicted band size: 96 kDa;

Observed band size: 99 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

Q14416

Gene ID

2912 [NCBI]

Immunogen

A synthetic peptide of human Metabotropic Glutamate Receptor 2

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100

Pureza	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (By similarity). Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization; (Microbial infection) Plays an important role in influenza virus internalization; (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of GRM2 to enter cells; (Microbial infection) Acts as a host entry factor for SARS-CoV-2 that hijacks the endocytosis of GRM2 to enter cells

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Synapse; Cell projection, dendrite

Expression：
Tissue_specificity:Protein levels were detected in the cerebral cortex. It is widely expressed in different regions of the human brain and in the fetal brain.

Subunit：Forms heterodimers with GRM3 or GRM4 (PubMed:37286794). Interacts with TAMALIN (By similarity). Interacts with HTR2A

Research Field

Neuroscience

Synonyms

GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 2; mGluR2; GRM3; GPRC1C; MGLUR3; Metabotropic glutamate receptor 3; mGluR3

Documentación

User Guide for Antibodies (1077 KB)