p38 beta/MAPK11 + p38 gamma/MAPK12 + p38 delta/MAPK13 Antibody (YA7069)

Cat. No.: HY-P87386: Data Sheet User Guide for Antibodies
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p38 beta/MAPK11 + p38 gamma/MAPK12 + p38 delta/MAPK13 Antibody (YA7069) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to p38 beta/MAPK11 + p38 gamma/MAPK12 + p38 delta/MAPK13.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 42 kDa;

Observed band size: 42 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat, Monkey

SwissProt ID

Q15759,P53778,O15264

Immunogen

Recombinant protein within human MAPK12 aa 1-367 / 367.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:2000

Sensitivity	Endogenous	Purity	Protein A affinity purified.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Q15759: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors (PubMed:12452429, PubMed:20626350, PubMed:35857590).
P53778: MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2.
O15264: MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2.

Subcellular Localization：Q15759: Cytoplasm, Nucleus
O15264: Cytoplasm, Nucleus, Mitochondrion

Expression：
Tissue specificity: Q15759: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
O15264: Highly expressed in skeletal muscle and heart.
Q15759: Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.
Induction: O15264: Expression of MAPK12 is down-regulation by MAPK14 activation.
Positive sample: 293T cell lysate, HeLa cell lysate, MCF7 cell lysate, K-562 cell lysate, MDA-MB-231 cell lysate, COS-1 cell lysate, RAW264.7 cell lysate, Neuro-2a cell lysate

Isoforms & Post-Translational Modification：Q15759 has two isomers: Q15759-1: 41,357 Da (predicted); Q15759-3: 23,603 Da (predicted).
Q15759 has two isomers: P53778-1: 41,940 Da (predicted); P53778-2: 40,808 Da (predicted).
Q15759 has two isomers: Q15759-1: 42,090 Da (predicted); Q15759-2: 28,779 Da (predicted).

Subunit：Q15759: Interacts with HDAC3 and DUSP16.
O15264: Monomer.
Q15759: Interacts with MAPK8IP2.

Synonyms

ERK 6 antibody; ERK-6 antibody; ERK6 antibody; Extracellular signal-regulated kinase 6 antibody; MAP kinase 12 antibody; MAP kinase p38 gamma antibody; MAPK 12 antibody; Mapk12 antibody; Mitogen Activated Protein Kinase 12 antibody; Mitogen activated protein kinase p38 gamma antibody

Documentation

User Guide for Antibodies (1077 KB)