Parathyroid Hormone Receptor 1 Antibody (YA4175)(PBS only)

Cat. No.: HY-P84478A: Data Sheet User Guide for Antibodies
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Parathyroid Hormone Receptor 1 Antibody (YA4175) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Parathyroid Hormone Receptor 1.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

Parathyroid Hormone Receptor 1 Antibody (YA4175) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Parathyroid Hormone Receptor 1.

Host

Mouse

분자량

Predicted band size: 66 kDa;

Observed band size: 66 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q03431

Gene ID

5745 [NCBI]

Immunogen

Purified recombinant fragment of human PTH1R aa 27-188.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (PubMed:30975883, PubMed:35932760). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:20172855, PubMed:30975883, PubMed:35932760). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (PubMed:35932760)

Subcellular Localization：Cell membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:It is expressed in most tissues, with the highest concentrations found in the kidneys, bones, and liver.

Subunit：Homodimer in the absence of bound ligand (PubMed:19674967, PubMed:20172855, PubMed:27160269, PubMed:30975883). Peptide hormone binding leads to dissociation of the homodimer (PubMed:19674967, PubMed:20172855)

Synonyms

PFE; PTHR; PTHR1; MGC138426; MGC138452; PTH1R

각종 서류

User Guide for Antibodies (1077 KB)