2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. PAX5 Antibody (YA5712)

PAX5 Antibody (YA5712) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to PAX5.

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容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

PAX5 Antibody (YA5712) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to PAX5.
Host

Mouse
Clonality

Monoclonal
分子量
Predicted band size: 42 kDa;
Observed band size: 42 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

Synthesized peptide derived from human PAX-5 AA range:300-383
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:200-400
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
1:500-5000
純度 affinity chromatography. Conjugation Non-conjugated
Modification Unmodified Isotype IgG
Appearance

Liquid
Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage (PubMed:10811620, PubMed:27181361). Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes (PubMed:10811620, PubMed:27181361). In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage (PubMed:32612238). Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire (PubMed:32612238); (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription (PubMed:31941781). Also participates in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity (PubMed:23678172)
Subcellular Localization：Nucleus
Isoforms & Post-Translational Modification：Q02548 has 11 isomers: Q02548-1: 42149 Da (predicted); Q02548-2: 38890 Da (predicted); Q02548-3: 35281 Da (predicted); Q02548-4: 32471 Da (predicted); Q02548-5: 31830 Da (predicted); Q02548-6: 38773 Da (predicted); Q02548-7: 35514 Da (predicted); Q02548-8: 37834 Da (predicted); Q02548-9: 34574 Da (predicted); Q02548-10: 31381 Da (predicted); Q02548-11: 34132 Da (predicted).
O-glycosylated;Phosphorylated by SYK. This phosphorylation plays an important role in the abolition of BLIMP1 repression by PAX5 in order to trigger plasma cell differentiation
Subunit：Interacts with ETS1; this interaction alters PAX5 DNA-binding properties (PubMed:11779502). Binds DNA as a monomer (PubMed:11779502). Interacts with TBP; this interaction allows PAX5 to interact with the basal transcription machinery (PubMed:10197586). Interacts with RB1 (PubMed:10197586). Interacts with TLE4 (PubMed:10811620). Interacts with DAXX (By similarity)
Synonyms
Paired box protein Pax-5; B-cell-specific transcription factor; BSAP;
ドキュメンテーション
User Guide for Antibodies (1077 KB)

PAX5 Antibody (YA5712) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
PAX5 Antibody (YA5712)
製品番号:
HY-P86020
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