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  5. Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody (YA229)(PBS only)

Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody (YA229)(PBS only)

製品番号: HY-P80787A
User Guide for Antibodies Technical Support

Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody (YA229) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Acetyl Coenzyme A Carboxylase (Ser79).

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容量 在庫状況
50 μL   お問い合わせ  
100 μL   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 説明

製品説明

Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody (YA229) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Acetyl Coenzyme A Carboxylase (Ser79).
Host

Rabbit
分子量
Predicted band size: 266 kDa;
Observed band size: 277 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Synthetic phosphopeptide corresponding to residues surrounding Ser79 of Human Acetyl Coenzyme A Carboxylase.The exact sequence is proprietary to MCE.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
純度 affinity purified Conjugation Non-conjugated
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
輸送条件

Shipping with blue ice.
Background
Function：Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443)
Subcellular Localization：Cytoplasm, cytosol
Expression：
Tissue_specificity:It is expressed in the brain, placenta, skeletal muscle, kidney, pancreas, and adipose tissue; it is expressed at low levels in lung tissue; and it was not detected in the liver.
Isoforms & Post-Translational Modification：Q13085 has 4 isomers: Q13085-1: 265554 Da (predicted); Q13085-2: 259686 Da (predicted); Q13085-3: 257239 Da (predicted); Q13085-4: 269999 Da (predicted).
Phosphorylation on Ser-1263 is required for interaction with BRCA1;Phosphorylation at Ser-80 by AMPK inactivates enzyme activity;The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity
Subunit：Monomer, homodimer, and homotetramer (PubMed:20952656, PubMed:29899443). Can form filamentous polymers (PubMed:20457939, PubMed:20952656, PubMed:29899443). Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis (PubMed:12360400, PubMed:16326698, PubMed:18452305, PubMed:29899443). Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity (PubMed:20457939)
Research Field

Cardiovascular
Synonyms
ACACA; ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha
ドキュメンテーション
User Guide for Antibodies (1077 KB)

Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody (YA229)(PBS only) 関連分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
Phospho-Acetyl Coenzyme A Carboxylase (Ser79) Antibody (YA229)(PBS only)
製品番号:
HY-P80787A
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