Phospho-Cyclin B1 (Ser126) Antibody (YA208)(PBS only)

製品番号: HY-P80806A: データシート User Guide for Antibodies
FAQs
Technical Support

Phospho-Cyclin B1 (Ser126) Antibody (YA208) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Cyclin B1 (Ser126).

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容量		在庫状況
50 μL		お問い合わせ
100 μL		お問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

Phospho-Cyclin B1 (Ser126) Antibody (YA208) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Cyclin B1 (Ser126).

Host

Rabbit

分子量

Predicted band size: 48 kDa;

Observed band size: 55 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P14635

Gene ID

891 [NCBI]

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding Ser126 of Human Cyclin B1.The exact sequence is proprietary to MCE.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IP IP: Immunoprecipitation	1:20

純度	affinity purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Essential for the control of the cell cycle at the G2/M (mitosis) transition

Subcellular Localization：Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Isoforms & Post-Translational Modification：P14635 has 2 isomers: P14635-1: 48337 Da (predicted); P14635-2: 44102 Da (predicted).
Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction (PubMed:16009132). Deubiquitinated by USP22 during G2/M phase (PubMed:27030811);Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site

Subunit：Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. Interacts with CDK5RAP3 (PubMed:15790566). Interacts with RFPL4A and UBE2A (By similarity). Interacts with INCA1 (PubMed:21540187)

Research Field

Cell Biology

Synonyms

CCNB1; CCNB; G2/mitotic-specific cyclin-B1

ドキュメンテーション

User Guide for Antibodies (1077 KB)

Phospho-Cyclin B1 (Ser126) Antibody (YA208)(PBS only) 関連分類

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Phospho-Cyclin B1 (Ser126) Antibody (YA208)(PBS only)

Product Detail

Background

説明

Phospho-Cyclin B1 (Ser126) Antibody (YA208)(PBS only) 関連分類

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