Polymeric immunoglobulin receptor/PIGR Antibody (YA7087)(PBS only)

Cat. No.: HY-P87399A: Data Sheet User Guide for Antibodies
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Polymeric immunoglobulin receptor/PIGR Antibody (YA7087) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Polymeric immunoglobulin receptor/PIGR.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Polymeric immunoglobulin receptor/PIGR Antibody (YA7087) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Polymeric immunoglobulin receptor/PIGR.

Host

Mouse

Molecular Weight

Predicted band size: 83.3kDa;

Species Reactivity

Human

SwissProt ID

P01833

Immunogen

Purified recombinant fragment of human PIGR (AA: extra 19-170) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Solution

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment|Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244)

Subcellular Localization：Cell membrane,Secreted

Isoforms & Post-Translational Modification：P01833: 764 amino acids, molecular weight 83284 Da.

Subunit：Interacts (mainly via CDR1-like domain) with dimeric IgA (PubMed:15530357)

Synonyms

Polymeric immunoglobulin receptor, PIgR, Poly-Ig receptor, Hepatocellular carcinoma-associated protein TB6, PIGR

Documentation

User Guide for Antibodies (1077 KB)