RNH1 (Ribonuclease Inhibitor) Antibody (YA8142)(PBS only)

Cat. No.: HY-P88458A: Data Sheet User Guide for Antibodies
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RNH1 (Ribonuclease Inhibitor) Antibody (YA8142) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RNH1 (Ribonuclease Inhibitor).

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

RNH1 (Ribonuclease Inhibitor) Antibody (YA8142) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RNH1 (Ribonuclease Inhibitor).

Host

Mouse

Molecular Weight

Predicted band size: 49.8 kDa

Species Reactivity

Human

SwissProt ID

P13489

Immunogen

Full length human recombinant protein of human RNH1 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG) (PubMed:12578357, PubMed:14515218, PubMed:3219362, PubMed:3243277, PubMed:3470787, PubMed:9050852). May play a role in redox homeostasis (PubMed:17292889). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (PubMed:23843625, PubMed:32510170). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (PubMed:23843625)

Subcellular Localization：Cytoplasm,Nucleus

Isoforms & Post-Translational Modification：P13489: 461 amino acids, molecular weight 49973 Da.

Subunit：Forms high-affinity heterodimers with RNASE1, ANG and RNASE2

Synonyms

RAI; RNH

Documentation

User Guide for Antibodies (1077 KB)