RUNX1T1 (ETO) Antibody (YA7856)(PBS only)

Cat. No.: HY-P88172A: Data Sheet User Guide for Antibodies
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RUNX1T1 (ETO) Antibody (YA7856) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RUNX1T1 (ETO).

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

RUNX1T1 (ETO) Antibody (YA7856) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RUNX1T1 (ETO).

Host

Mouse

Molecular Weight

Predicted band size: 63 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q06455

Immunogen

Full length human recombinant protein of human RUNX1T1 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Purity	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:10688654, PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588)

Subcellular Localization：Nucleus

Expression：
Tissue_Specificity: Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary

Isoforms & Post-Translational Modification：Q06455 has 6 isomers: Q06455-1: 67566 Da (predicted); Q06455-2: 64396 Da (predicted); Q06455-3: 68746 Da (predicted); Q06455-4: 63212 Da (predicted); Q06455-5: 48146 Da (predicted); Q06455-6: 44975 Da (predicted).

Subunit：Homooligomer

Synonyms

AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2

Documentation

User Guide for Antibodies (1077 KB)