Sarcomeric alpha Actinin Antibody (YA1903)(PBS only)

Cat. No.: HY-P82158A: Ficha de datos User Guide for Antibodies
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Sarcomeric alpha Actinin Antibody (YA1903) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Sarcomeric alpha Actinin.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn
Referencias

Descripciòn

Sarcomeric alpha Actinin Antibody (YA1903) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Sarcomeric alpha Actinin.

Host

Rabbit

Peso molecular

Predicted band size: 104 kDa;

Observed band size: 104 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P35609

Gene ID

88 [NCBI]

Immunogen

A synthetic peptide of human Sarcomeric Alpha Actinin aa1-14.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100
IP IP: Immunoprecipitation	1:20

Pureza	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein

Subcellular Localization：Cytoplasm, myofibril, sarcomere, Z line

Expression：
Tissue_specificity:It is expressed in both skeletal muscle and cardiac muscle.

Isoforms & Post-Translational Modification：P35609 has 2 isomers: P35609-1: 103854 Da (predicted); P35609-2: 103920 Da (predicted).
Ubiquitinated by FBXL22, leading to proteasomal degradation

Subunit：Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2. Interacts with DST isoform 1 (via N-terminus). Interacts with PARVB. Interacts with SYNPO2

Research Field

Signal Transduction

Synonyms

Actin binding protein; Actinin alpha 2; ACTN2; Alpha actinin 2; CMD1AA

Documentación

User Guide for Antibodies (1077 KB)

Referencias

[1]. /biology-dictionary/nci-h460-cell.html [Content Brief]