SLC1A5/ASCT2 Antibody (YA1180)(PBS only)

Art. -Nr.: HY-P81435A: Data Sheet User Guide for Antibodies
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SLC1A5/ASCT2 Antibody (YA1180) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC1A5/ASCT2.

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Größe		Verfügbarkeit
50 μL		Angebot einholen
100 μL		Angebot einholen

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung
Verweise

Beschreibung

SLC1A5/ASCT2 Antibody (YA1180) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC1A5/ASCT2.

Host

Rabbit

Molekulargewicht

Predicted band size: 57 kDa;

Observed band size: 57 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q15758

Gene ID

6510 [NCBI]

Immunogen

A synthesized peptide derived from human SLC1A5

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

Reinheit	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:17094966, PubMed:23756778, PubMed:26492990, PubMed:29872227, PubMed:34741534, PubMed:8702519). The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine witH2O2her neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation (PubMed:23756778, PubMed:24953180). The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system (PubMed:32733894). Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons (PubMed:17094966). Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity). TH2O2gh binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904); (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114; (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus; (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Melanosome

Expression：
Tissue_specificity:Placenta, lung, skeletal muscle, kidney, pancreas, and intestine (PubMed:8702519) . Expressed in CD34-positive hematopoietic progenitors (at protein level) (PubMed:24953180)

Isoforms & Post-Translational Modification：Q15758 has 3 isomers: Q15758-1: 56598 Da (predicted); Q15758-2: 36636 Da (predicted); Q15758-3: 33710 Da (predicted).

Subunit：Homotrimer (Probable) (PubMed:29872227). Interacts with ERVH48-1/suppressyn; may negatively regulate syncytialization (PubMed:23492904)

Research Field

Microbiology

Synonyms

SLC1A5 ; ASCT2; M7V1, RDR, RDRC; Neutral amino acid transporter B(0); ATB(0); Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5

Dokumentation

User Guide for Antibodies (1077 KB)

Verweise

[1]. /biology-dictionary/ovcar-3-cell.html [Content Brief]