Somatostatin Receptor 2 Antibody (YA3946)(PBS only)

Cat. No.: HY-P84249A: Data Sheet User Guide for Antibodies
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Somatostatin Receptor 2 Antibody (YA3946) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Somatostatin Receptor 2.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

Somatostatin Receptor 2 Antibody (YA3946) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Somatostatin Receptor 2.

Host

Mouse

분자량

Predicted band size: 41.3 kDa;

Observed band size: 42 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P30874

Gene ID

6752 [NCBI]

Immunogen

Purified recombinant fragment of human SSTR2 expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Purity	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Solution

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Cytoplasm

Expression：
Tissue_specificity:It is expressed (at protein levels) in both pancreatic α and β cells. Its expression level in the pancreas is higher than other somatostatin receptors. It is also expressed in the brain and kidneys, but less so in the jejunum, colon, and liver. In the developing nervous system, it is expressed in the cortex of the anterior plate in early stages, and enriched in the outer layer of the germinal area in later stages. In the cerebellum, it is expressed in the deep layers of the outer granular layer at 19 weeks of gestation. This expression pattern persists until birth but disappears in adulthood.

Isoforms & Post-Translational Modification：P30874 has 2 isomers: P30874-1: 41333 Da (predicted); P30874-2: 40007 Da (predicted).
Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity)

Subunit：Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain)

Synonyms

Somatostatin receptor type 2, SS-2-R, SS2-R, SS2R, SST2, SRIF-1, SSTR2

각종 서류

User Guide for Antibodies (1077 KB)