TOLLIP Antibody (YA7789)(PBS only)

Art. -Nr.: HY-P88105A: Data Sheet User Guide for Antibodies
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TOLLIP Antibody (YA7789) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TOLLIP.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Größe		Verfügbarkeit
50 μL		Angebot einholen
100 μL		Angebot einholen

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung

Beschreibung

TOLLIP Antibody (YA7789) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TOLLIP.

Host

Mouse

Molekulargewicht

Predicted band size: 30.1 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9H0E2

Immunogen

Full length human recombinant protein of human TOLLIP produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250

Reinheit	Affinity purified	Conjugation	Non-conjugated
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Component of the signaling pathway of IL-1 and Toll-like receptors (PubMed:10854325, PubMed:11751856). Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex (PubMed:10854325). Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (PubMed:25042851). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:26320582)

Subcellular Localization：Cytoplasm,Endosome,Early endosome

Isoforms & Post-Translational Modification：Q9H0E2 has two isomers: Q9H0E2-1: 30282 Da (predicted); Q9H0E2-2: 22812 Da (predicted).
Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products

Subunit：Oligomerizes (PubMed:11751856)

Synonyms

IL-1RAcPIP

Dokumentation

User Guide for Antibodies (1077 KB)