TSH Receptor/TSH-R Antibody (YA1252)(PBS only)

製品番号: HY-P81507A: データシート User Guide for Antibodies
FAQs
Technical Support

TSH Receptor/TSH-R Antibody (YA1252) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TSH Receptor/TSH-R.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量		在庫状況
50 μL		お問い合わせ
100 μL		お問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

TSH Receptor/TSH-R Antibody (YA1252) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TSH Receptor/TSH-R.

Host

Rabbit

分子量

Predicted band size: 86 kDa;

Observed band size: 86 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P16473

Gene ID

7253 [NCBI]

Immunogen

Recombinant protein of human TSH Receptor

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:500-1:1000

純度	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:11847099, PubMed:12045258). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099). Plays a central role in controlling thyroid cell metabolism (By similarity)

Subcellular Localization：Cell membrane; Multi-pass membrane protein; Basolateral cell membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Expressed in thyroide cells (at protein level) (PubMed:11847099) . Expressed in the thyroid (PubMed:2610690)

Isoforms & Post-Translational Modification：P16473 has 3 isomers: P16473-1: 86844 Da (predicted); P16473-2: 28427 Da (predicted); P16473-3: 30800 Da (predicted).
Glycosylated;Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation

Subunit：Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production (PubMed:12045258). Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function (PubMed:15775968)

Research Field

Signal Transduction

Synonyms

LGR3; TSHR; Thyrotropin Receptor; Thyroid-stimulating hormone receptor (TSH-R)

ドキュメンテーション

User Guide for Antibodies (1077 KB)

TSH Receptor/TSH-R Antibody (YA1252)(PBS only) 関連分類

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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TSH Receptor/TSH-R Antibody (YA1252)(PBS only)

Product Detail

Background

説明

TSH Receptor/TSH-R Antibody (YA1252)(PBS only) 関連分類

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