YKL-40/CHI3L1 Antibody (YA6959)

製品番号: HY-P87276: データシート SDS COA User Guide for Antibodies
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YKL-40/CHI3L1 Antibody (YA6959) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to YKL-40/CHI3L1.

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容量	価格（税別）	在庫状況	数量
10 μL	$93	在庫あり	Estimated Time of Arrival: December 31
50 μL	$240	在庫あり	Estimated Time of Arrival: December 31
100 μL	$384	在庫あり	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明
参考文献

製品説明

YKL-40/CHI3L1 Antibody (YA6959) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to YKL-40/CHI3L1.

Host

Mouse

Clonality

Monoclonal

分子量

Predicted band size: 43 kDa;

Observed band size: 43 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P36222

Immunogen

Recombinant protein within extracellular domain of Human CHI3L1.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:200

Sensitivity	Endogenous	純度	Protein G affinity purified.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung

Subcellular Localization：Secreted, extracellular space,Cytoplasm,Cytoplasm, perinuclear region,Endoplasmic reticulum

Expression：
Tissue_Specificity: Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts
Induction: Up-regulated in colon under several inflammatory conditions. Down-regulated by hyperoxia in bronchial epithelial cells

Subunit：Monomer

Synonyms

39 kDa synovial protein antibody; ASRT7 antibody; Cartilage glycoprotein 39 antibody; CGP-39 antibody; CGP39 antibody; CH3L1_HUMAN antibody; CHI3L1 antibody; chitinase 3 like 1 (cartilage glycoprotein 39) antibody; chitinase 3 like 1 antibody; Chitinase 3 like protein 1 precursor antibody

ドキュメンテーション

Select Batch:

データシート (231 KB) SDS (252 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

参考文献

[1]. /biology-dictionary/huh-7-cell.html [Content Brief]