ZFYVE1 Antibody (YA8789)

Cat. No.: HY-P89105: Data Sheet User Guide for Antibodies
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ZFYVE1 Antibody (YA8789) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFYVE1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

ZFYVE1 Antibody (YA8789) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZFYVE1.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 40.1 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9HBF4

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-308 of human ZFYVE1 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:500-800

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:30970241, PubMed:31293035). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11256955, PubMed:11739631)|(Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, mediates through binding with non-structural protein 6 (nsp6) the replication organelle-lipid droplet association required to sustain viral replication

Subcellular Localization：Golgi apparatus, Golgi stack,Golgi apparatus,Endoplasmic reticulum,Lipid droplet,Preautophagosomal structure,Mitochondrion

Expression：
Tissue_Specificity: Highly expressed in heart. Also detected in the testis|Expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Highly expressed in heart

Isoforms & Post-Translational Modification：Q9HBF4 has three isomers: Q9HBF4-1: 87176 Da (predicted); Q9HBF4-2: 40260 Da (predicted); Q9HBF4-3: 85592 Da (predicted).

Subunit：Interacts with RAB18 (in GTP-bound form) (PubMed:30970241, PubMed:31293035)

Synonyms

DFCP1; PPP1R172; SR3; TAFF1; ZNFN2A1

Documentation

User Guide for Antibodies (1077 KB)