Apoptosis inducer 59
Apoptosis inducer 59, a camphorsulfonamide-based thiazolylhydrazone derivative, is a apoptosis inducer with antitumor activity. Apoptosis inducer 59 can inhibit cell migration and invasiveness, cause S phase arrest, induce ROS production and depolarise mitochondrial membrane potential. Apoptosis inducer 59 can be used for the research of cancer, such as breast cancer.
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- Formule: C25H27ClN4O3S2
- Masse moléculaire:531.09
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
Apoptosis inducer 59 (Compound 5J) (48 h) potently and selectively inhibits MCF-7 breast cancer cell proliferation with an IC50 of 12.80 ± 0.12 μM, while exhibiting low cytotoxicity to normal LO2 liver cells (IC50 >50 μM)[1].
Apoptosis inducer 59 (5-25 μM; 24 h) dose-dependently induces apoptosis in MCF-7 breast cancer cells, with a combined early and late apoptosis rate of 25.52%[1].
Apoptosis inducer 59 (5-25 μM; 24 h) induces S phase cell cycle arrest in MCF-7 breast cancer cells, increasing the S phase population from 21.78% to 31.32%[1].
Apoptosis inducer 59 (5-25 μM; 24-48 h) inhibits MCF-7 breast cancer cell migration and invasiveness[1].
Apoptosis inducer 59 (5-25 μM) dose-dependently increases intracellular ROS production in MCF-7 breast cancer cells[1].
Apoptosis inducer 59 (5-25 μM) concentration-dependently depolarizes the mitochondrial membrane potential in MCF-7 breast cancer cells, leading to mitochondrial dysfunction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 breast cancer cells
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Concentration:5, 10 and 25 μM
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Incubation Time:24 h
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Result:Increased apoptosis rates in MCF-7 cells
(10.62%, 11.60%, 18.17%).
Showed early and late apoptosis rate of 25.52% higher than the control group (9.50%).
Chemical Information
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Masse moléculaire 531.09
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Formule C25H27ClN4O3S2
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SMILES
O=S(CC1(C2(C)C)/C(CC2CC1)=N/NC3=NC(C4=CC=C(O)C=C4)=CS3)(NC5=CC=CC(Cl)=C5)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 59 Related Classifications
HY-181274 Related Classifications
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