Apoptosis inducer 59 

Apoptosis inducer 59, a camphorsulfonamide-based thiazolylhydrazone derivative, is a apoptosis inducer with antitumor activity. Apoptosis inducer 59 can inhibit cell migration and invasiveness, cause S phase arrest, induce ROS production and depolarise mitochondrial membrane potential. Apoptosis inducer 59 can be used for the research of cancer, such as breast cancer^[1].

Apoptosis inducer 59 (Compound 5J) (48 h) potently and selectively inhibits MCF-7 breast cancer cell proliferation with an IC₅₀ of 12.80 ± 0.12 μM, while exhibiting low cytotoxicity to normal LO2 liver cells (IC₅₀ >50 μM)^[1].
Apoptosis inducer 59 (5-25 μM; 24 h) dose-dependently induces apoptosis in MCF-7 breast cancer cells, with a combined early and late apoptosis rate of 25.52%^[1].
Apoptosis inducer 59 (5-25 μM; 24 h) induces S phase cell cycle arrest in MCF-7 breast cancer cells, increasing the S phase population from 21.78% to 31.32%^[1].
Apoptosis inducer 59 (5-25 μM; 24-48 h) inhibits MCF-7 breast cancer cell migration and invasiveness^[1].
Apoptosis inducer 59 (5-25 μM) dose-dependently increases intracellular ROS production in MCF-7 breast cancer cells^[1].
Apoptosis inducer 59 (5-25 μM) concentration-dependently depolarizes the mitochondrial membrane potential in MCF-7 breast cancer cells, leading to mitochondrial dysfunction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

531.09

C₂₅H₂₇ClN₄O₃S₂

O=S(CC1(C2(C)C)/C(CC2CC1)=N/NC3=NC(C4=CC=C(O)C=C4)=CS3)(NC5=CC=CC(Cl)=C5)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang YY, et al. Design, synthesis, and anticancer activity of novel camphorsulfonamide-based thiazolylhydrazone derivatives. Nat Prod Res. Published online January 5, 2026.  [Content Brief]