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ARN-509 Chemical Structure
|Product name: ARN-509|
|Cat. No.: HY-16060|
ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM, useful for prostate cancer treatment.
IC50 value: 16 nM
Target: androgen receptor
ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.
|M.Wt||477.43||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO 15 mg/mL Ethanol 5 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||2.0945 mL||10.4727 mL||20.9455 mL|
|5 mM||0.4189 mL||2.0945 mL||4.1891 mL|
|10 mM||0.2095 mL||1.0473 mL||2.0945 mL|
|Product Name||Sponsor Only||Condition||Start Date||End Date||Phase||Last Change Date|
|ARN-509||Aragon Pharmaceuticals Inc||Hormone refractory prostate cancer||31-JUL-10||30-JUN-13||Phase 2||17-SEP-13|
|Aragon Pharmaceuticals Inc||31-MAR-13||30-JUN-13||Phase 1||17-SEP-13|
|Aragon Pharmaceuticals Inc||Hormone refractory prostate cancer||31-OCT-13||31-DEC-16||Phase 3||05-NOV-13|
|Aragon Pharmaceuticals Inc; Johnson & Johnson||Hormone refractory prostate cancer||28-FEB-13||01-FEB-14||Phase 1||07-OCT-13|
|Aragon Pharmaceuticals Inc||Hormone dependent prostate cancer||28-FEB-13||28-FEB-18||Phase 2||18-OCT-13|
. Schweizer MT, Antonarakis ES. Abiraterone and other novel androgen-directed strategies for the treatment of prostate cancer: a new era of hormonal therapies is born. Ther Adv Urol. 2012 Aug;4(4):167-78.
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