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Signaling Pathway

ARN-509

HY-16060

(Apalutamide)

ARN-509

ARN-509 Chemical Structure

ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM, useful for prostate cancer treatment.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $88 In-stock
5 mg $80 In-stock
10 mg $140 In-stock
50 mg $350 In-stock
100 mg $550 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €86 In-stock
5 mg €78 In-stock
10 mg €137 In-stock
50 mg €343 In-stock
100 mg €539 In-stock
200 mg Get quote
500 mg Get quote

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Product name: ARN-509
Cat. No.: HY-16060

ARN-509 Data Sheet

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    Purity: 99.68%

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Biological Activity of ARN-509

ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM, useful for prostate cancer treatment.
IC50 value: 16 nM
Target: androgen receptor
ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.

Chemical Information

M.Wt 477.43 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C21H15F4N5O2S
CAS No 956104-40-8
Solvent & Solubility

DMSO 15 mg/mL Ethanol 5 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.0945 mL 10.4727 mL 20.9455 mL
5 mM 0.4189 mL 2.0945 mL 4.1891 mL
10 mM 0.2095 mL 1.0473 mL 2.0945 mL

Clinical Information of ARN-509

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
ARN-509 Aragon Pharmaceuticals Inc Hormone refractory prostate cancer 31-JUL-10 30-JUN-13 Phase 2 17-SEP-13
Aragon Pharmaceuticals Inc 31-MAR-13 30-JUN-13 Phase 1 17-SEP-13
Aragon Pharmaceuticals Inc Hormone refractory prostate cancer 31-OCT-13 31-DEC-16 Phase 3 05-NOV-13
Aragon Pharmaceuticals Inc; Johnson & Johnson Hormone refractory prostate cancer 28-FEB-13 01-FEB-14 Phase 1 07-OCT-13
Aragon Pharmaceuticals Inc Hormone dependent prostate cancer 28-FEB-13 28-FEB-18 Phase 2 18-OCT-13

References on ARN-509

Inhibitor Kit

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