1. Apoptosis
  2. Bcl-2 Family
  3. BCL6-IN-8c

BCL6-IN-8c 

Cat. No.: HY-119402
Handling Instructions

BCL6-IN-8c is a potent and orally active B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor with an IC50 of 0.10 µM in cell-free enzyme-linked immunosorbent assay.

For research use only. We do not sell to patients.

BCL6-IN-8c Chemical Structure

BCL6-IN-8c Chemical Structure

CAS No. : 2130878-25-8

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Description

BCL6-IN-8c is a potent and orally active B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor with an IC50 of 0.10 µM in cell-free enzyme-linked immunosorbent assay[1].

IC50 & Target

IC50: 0.10 µM (B-cell lymphoma 6 (BCL6)-corepressor interaction)[1]

In Vitro

BCL6-IN-8c (Compound 8c) also exhibits good cellular PPI inhibitory activity in the submicromolar range (M2H IC50 = 0.72 µM). BCL6-IN-8c does not exhibit significant cytotoxicity even at 30 µM[1].

In Vivo

The pharmacokinetic profile of BCL6-IN-8c (Compound 8c) is evaluated by a mouse cassette-dosing study (0.1 mg/kg iv; 1 mg/kg po). BCL6-IN-8c exhibits a good pharmacokinetic profile (Cmax = 233 ng/mL, Tmax = 2 hours, MRT = 3.3 h, AUC = 1.27 mg•h/mL, F (oral bioavailability) = 79.9%)[1].

Molecular Weight

417.84

Formula

C₂₀H₂₀ClN₃O₅

CAS No.

2130878-25-8

SMILES

O=C1NC2=C(CC1)C=C(C=C2)NC3=CC(OC4CCOCC4)=C(C=C3Cl)[N+]([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BCL6-IN-8cBcl-2 FamilyPharmacokineticprofileorallynon-cytotoxicityprotein-proteininteractionsBCL6Inhibitorinhibitorinhibit

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BCL6-IN-8c
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HY-119402
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