C-type lectin domain family 4 member M

Definition:

Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.; (Microbial infection) Acts as an attachment receptor for Ebolavirus.; (Microbial infection) Acts as an attachment receptor for Hepatitis C virus.; (Microbial infection) Acts as an attachment receptor for HIV-1.; (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.; (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.; (Microbial infection) Acts as an attachment receptor for Influenzavirus.; (Microbial infection) Acts as an attachment receptor for SARS-CoV.; (Microbial infection) Acts as an attachment receptor for West-nile virus.; (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.; (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.; (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.

References:

[1]. A A Bashirova, et al. A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection. J Exp Med. 2001 Mar 19;193(6):671-8. [Content Brief]

[2]. Scott A Jeffers, et al. Human coronavirus 229E can use CD209L (L-SIGN) to enter cells. Adv Exp Med Biol. 2006;581:265-9. [Content Brief]

[3]. Maria V Carroll, et al. Identification of four novel DC-SIGN ligands on Mycobacterium bovis BCG. Protein Cell. 2010 Sep;1(9):859-70. [Content Brief]

[4]. Ronaldo Celerino da Silva, et al. Role of DC-SIGN and L-SIGN receptors in HIV-1 vertical transmission. Hum Immunol. 2011 Apr;72(4):305-11. [Content Brief]

[5]. Carmen P Alvarez, et al. C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. J Virol. 2002 Jul;76(13):6841-4. [Content Brief]

[6]. Masayuki Shimojima, et al. Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin. Arch Virol. 2014 Aug;159(8):2023-31. [Content Brief]

[7]. Franck Halary, et al. Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection. Immunity. 2002 Nov;17(5):653-64. [Content Brief]

[8]. Wai K Lai, et al. Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles. Am J Pathol. 2006 Jul;169(1):200-8. [Content Brief]

[9]. Emmanuel G Cormier, et al. L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14067-72. [Content Brief]

[10]. Andrea Marzi, et al. DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus. J Virol. 2004 Nov;78(21):12090-5. [Content Brief]

[11]. Sarah L Londrigan, et al. N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN. J Virol. 2011 Mar;85(6):2990-3000. [Content Brief]

[12]. George Lin, et al. Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR. J Virol. 2003 Jan;77(2):1337-46. [Content Brief]

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