Calcium release-activated calcium channel protein 1

Definition:

Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Plays a prominent role in Ca(2+) influx at the basolateral membrane of mammary epithelial cells independently of the Ca(2+) content of endoplasmic reticulum or Golgi stores. May mediate transepithelial transport of large quantities of Ca(2+) for milk secretion.

References:

[1]. Mingye Feng, et al. Store-independent activation of Orai1 by SPCA2 in mammary tumors. Cell. 2010 Oct 1;143(1):84-98. [Content Brief]

[2]. Christine Peinelt, et al. Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat Cell Biol. 2006 Jul;8(7):771-3. [Content Brief]

[3]. Jeong-Eun Lee, et al. Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization. Mol Cells. 2013 Jan;35(1):41-6. [Content Brief]

[4]. M Vig, et al. CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science. 2006 May 26;312(5777):1220-3. [Content Brief]

[5]. Kathrin Dörr, et al. Cell type-specific glycosylation of Orai1 modulates store-operated Ca2+ entry. Sci Signal. 2016 Mar 8;9(418):ra25. [Content Brief]

[6]. Peter B Stathopulos, et al. STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry. Nat Commun. 2013;4:2963. [Content Brief]

[7]. Jonathan Soboloff, et al. Orai1 and STIM reconstitute store-operated calcium channel function. J Biol Chem. 2006 Jul 28;281(30):20661-20665. [Content Brief]

[8]. Stefan Feske, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006 May 11;441(7090):179-85. [Content Brief]

[9]. Tsipi Ben-Kasus Nissim, et al. Mitochondria control store-operated Ca2+ entry through Na+ and redox signals. EMBO J. 2017 Mar 15;36(6):797-815. [Content Brief]

[10]. Chan Young Park, et al. STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell. 2009 Mar 6;136(5):876-90. [Content Brief]

[11]. Ivan Bogeski, et al. Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. Sci Signal. 2010 Mar 30;3(115):ra24. [Content Brief]

[12]. Vasyl Nesin, et al. Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4197-202. [Content Brief]

[13]. Jason C Mercer, et al. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem. 2006 Aug 25;281(34):24979-90. [Content Brief]

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