Tubulinyl-Tyr carboxypeptidase 1

Definition

Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts.

References:

[1]. Joppe Nieuwenhuis, et al. Vasohibins encode tubulin detyrosinating activity. Science. 2017 Dec 15;358(6369):1453-1456. [Content Brief]

[2]. Faxiang Li, et al. Structural basis of tubulin detyrosination by vasohibins. Nat Struct Mol Biol. 2019 Jul;26(7):583-591. [Content Brief]

[3]. Na Wang, et al. Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex. Nat Struct Mol Biol. 2019 Jul;26(7):571-582. [Content Brief]

[4]. Kazuhide Watanabe, et al. Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis. J Clin Invest. 2004 Oct;114(7):898-907. [Content Brief]

[5]. Athanassios Adamopoulos, et al. Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP. Nat Struct Mol Biol. 2019 Jul;26(7):567-570. [Content Brief]

[6]. Shanhui Liao, et al. Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res. 2019 Jul;29(7):533-547. [Content Brief]

[7]. Hiroshi Yamashita, et al. Vasohibin prevents arterial neointimal formation through angiogenesis inhibition. Biochem Biophys Res Commun. 2006 Jul 7;345(3):919-25. [Content Brief]

[8]. Hiroshi Kimura, et al. Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis. Blood. 2009 May 7;113(19):4810-8. [Content Brief]

[9]. Hikaru Sonoda, et al. Multiple processing forms and their biological activities of a novel angiogenesis inhibitor vasohibin. Biochem Biophys Res Commun. 2006 Apr 7;342(2):640-6. [Content Brief]

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