2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. c-Met-IN-21

c-Met-IN-21 (compound 54) is a c-met inhibitor with an IC50 value of 0.45? nM, and shows anti-tumor efficacy in vivo.

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c-Met-IN-21

c-Met-IN-21 Chemische Struktur

CAS. Nr. : 3025958-01-1

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c-Met-IN-21 Related Antibodies

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Beschreibung

c-Met-IN-21 (compound 54) is a c-met inhibitor with an IC50 value of 0.45? nM, and shows anti-tumor efficacy in vivo[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
>20 μM
Compound: 54
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38086189]
L02 IC50
>20 μM
Compound: 54
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38086189]
MHCC97H IC50
1.03 nM
Compound: 54
Antiproliferative activity against human MHCC97H cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MHCC97H cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38086189]
Molekulargewicht

610.66

Formel

C33H32F2N8O2
CAS. Nr.
SMILES

FC(F)(C1=NN=C2C=CC(C(C=C3CC4)=CC=C3N(CC(N5CCN(C(C)C)CC5)=O)C4=O)=NN12)C6=CC=C7C(C=CC=N7)=C6
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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c-Met-IN-21 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Met-IN-213025958-01-1c-Met/HGFRHepatocellular carcinomaSelectivityStructural optimizationc-Met inhibitorInhibitorinhibitorinhibit

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