Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
231 Results for "
hepg2-cell
" in MedChemExpress (MCE) Product Catalog:
Products (231)
231 Results for "hepg2-cell" in MCE Product Catalog:
21
Category:
Human Gut Microbiota Metabolites Flavonoids Flavones Citrus limon (L.) Burm. F. Rutaceae Plants Endogenous metabolite Disease Research Fields Cancer
Target:
21
Category:
Human Gut Microbiota Metabolites Flavonoids Citrus limon (L.) Burm. F. Rutaceae Plants Endogenous metabolite Disease Research Fields Cancer
Target:
20
20
20 Cited Publications
Synonyms: BMS200475 monohydrate; SQ34676 monohydrate
Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
18
18 Cited Publications
Target:
Research Areas:
CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively.
CAY10566 also shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM) [2].
13
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects [2] .
13
13 Cited Publications
Cat. No.: HY-B0144
CAS No.: 147526-32-7
Synonyms: NK-104 hemicalcium; Pitavastatin hemicalcium
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects [2] .
12
Category:
Alkaloids Piperidine Alkaloids Solanum Plants Solanaceae Disease Research Fields Saccharides Cancer Steroids
Target:
10
10 Cited Publications
Cat. No.: HY-19937
CAS No.: 495399-09-2
Target:
Research Areas:
Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.
10
10 Cited Publications
Cat. No.: HY-19937A
CAS No.: 1639792-20-3
Target:
Research Areas:
Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.
8
7
6
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Azilsartan (TAK-536) is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research [2] .
5
5 Cited Publications
Synonyms: 7-Hydroxycoumarin; Hydrangin; NSC 19790
Category:
Monophenols Coumarins Phenols Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer
Target:
4
Target:
Research Areas:
(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively .
4
4 Cited Publications
Cat. No.: HY-N0396
CAS No.: 19210-12-9
Category:
Iridoids Terpenoids Pedaliaceae Plants Disease Research Fields Inflammation/Immunology Harpagophytum procumbens
Target:
4
Category:
3
3 Cited Publications
Cat. No.: HY-N0316
CAS No.: 55481-88-4
3
3
3 Cited Publications
Cat. No.: HY-B0852
CAS No.: 107534-96-3
Research Areas:
Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells [2] .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
