464-74-4
464-74-4
Chemical Structure
Arenobufagin
- CAS No.: 464-74-4
- Formula:C24H32O6
- Molecular Weight:416.51
IUPAC Name: 5-((3S,5R,8R,9S,10S,11S,13R,14S,17R)-3,11,14-trihydroxy-10,13-dimethyl-12-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one
InChIKey: JGDCRWYOMWSTFC-AZGSIFHYSA-N
SMILES: C[C@]([C@@H](C(C=C1)=COC1=O)CC2)(C3=O)[C@]2([C@@](CC[C@@]4([H])[C@@]5(CC[C@H](O)C4)C)([H])[C@]5([H])[C@@H]3O)O
Biological Activity: Arenobufagin is a natural bufadienolide that can be extracted from toad venom. Arenobufagin can induce apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Arenobufagin has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells. Arenobufagin can inhibit VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway[1][2].
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Arenobufagin | 99.82% | Arenobufagin is a natural bufadienolide that can be extracted from toad venom. Arenobufagin can induce apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Arenobufagin has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells. Arenobufagin can inhibit VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. | ||||||||||||||||||||
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Arenobufagin (Standard) | ≥98% | Arenobufagin is a natural bufadienolide that can be extracted from toad venom. Arenobufagin can induce apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Arenobufagin has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells. Arenobufagin can inhibit VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. | ||||||||||||||||||||
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Bufalin (Standard) | ≥98% | Bufalin (Standard) is the analytical standard of Bufalin. This product is intended for research and analytical applications. Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively. Anti-cancer activity. | ||||||||||||||||||||
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Pseudobufarenogin | 99.29% | Pseudobufarenogin (ψ-Bufarenogin) is an extract of toad venom with an unknown activity background. | ||||||||||||||||||||
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Gamabufotalin (Standard) | ≥98% | Gamabufotalin (Gamabufagin), a main active compound isolated from Chinese medicine Chansu, has been shown to strongly inhibit cancer cell growth and inflammatory response. Gamabufotalin could inhibite angiogenesis by inhibiting the activation of VEGFR-2 signaling pathways. | ||||||||||||||||||||
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3-epi-Bufalin | 99.01% | 3-epi-Bufalin (compound 2a) is the microbial transformation product of bufadienolide. | ||||||||||||||||||||
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Desacetylbufotalin | Desacetylbufotalin (Bufogenin B; Deacetylbufotalin) is a bufadienolide found in Chinese drug "Chan'Su". Desacetylbufotalin shows strong anti-proliferative activity on the of Hela cells (IC50 = 0.01 μM). Desacetylbufotalin can be used for the research of cancer, such as cervical cancer. | |||||||||||||||||||||
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Arenobufagin 3-hemisuberate | Arenobufagin 3-hemisuberate is a natural compound as a cardiotonic steroid isolated from the skin of Japanese toad. | |||||||||||||||||||||
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Bufarenogin | 99.36% | Bufarenogin induces intrinsic apoptosis via Bax and ANT cooperation. | ||||||||||||||||||||
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7β-Hydroxybufalin | 7β-Hydroxybufalin is a bufadienolide. 7β-Hydroxybufalin can be isolated from the venom of Bufo bufo gargarizans. 7β-Hydroxybufalin inhibits α-glucosidase and acetylcholinesterase. | |||||||||||||||||||||
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Acetylarenobufagin | 98.63% | Acetylarenobufagin is a steroidal hypoxia inducible factor-1 (HIF-I) modulator. | ||||||||||||||||||||
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Argentinogenin | 99.58% | Argentinogenin is a natural compound with anti-cancer activity that could be found in traditional Chinese agent Chan Su. | ||||||||||||||||||||
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References
- [1]. Zhang DM, et al. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis. 2013 Jun;34(6):1331-42. [Content Brief]
- [2]. Li M, et al. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012 May 1;83(9):1251-60. [Content Brief]
