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Desacetylbufotalin  (Synonyms: Bufogenin B; Deacetylbufotalin)

Cat. No.: HY-N16671
Handling Instructions Technical Support

Desacetylbufotalin (Bufogenin B; Deacetylbufotalin) is a bufadienolide found in Chinese drug "Chan'Su". Desacetylbufotalin shows strong anti-proliferative activity on the of Hela cells (IC50 = 0.01 μM). Desacetylbufotalin can be used for the research of cancer, such as cervical cancer.

For research use only. We do not sell to patients.

Desacetylbufotalin

Desacetylbufotalin Chemical Structure

CAS No. : 465-19-0

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Desacetylbufotalin Related Antibodies

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Description

Desacetylbufotalin (Bufogenin B; Deacetylbufotalin) is a bufadienolide found in Chinese drug "Chan'Su". Desacetylbufotalin shows strong anti-proliferative activity on the of Hela cells (IC50 = 0.01 μM). Desacetylbufotalin can be used for the research of cancer, such as cervical cancer[1].

Cellular Effect
Cell Line Type Value Description References
CCRF S-180 IC50
> 50 μM
Compound: 3
Cytotoxicity against mouse S180 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against mouse S180 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23799775]
CNE IC50
4.893 μM
Compound: 3
Cytotoxicity against human CNE1 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human CNE1 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23799775]
CNE2Z IC50
1.765 μM
Compound: 3
Cytotoxicity against human CNE2Z cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human CNE2Z cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23799775]
H22 IC50
> 50 μM
Compound: 3
Cytotoxicity against mouse H22 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against mouse H22 cells expressing mutated alpha-1 Na+/K+-ATPase assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23799775]
HL-60 IC50
0.025 μg/mL
Compound: 18
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 11575946]
HepG2 IC50
2.595 μM
Compound: 3
Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against adriamycin-resistant human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23799775]
HepG2 IC50
3.584 μM
Compound: 3
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
[PMID: 23799775]
KB IC50
0.79 μg/mL
Compound: 18
Cytotoxicity against human KB cells after 72 hrs by MTT assay
Cytotoxicity against human KB cells after 72 hrs by MTT assay
[PMID: 11575946]
MH60 IC50
> 25 μg/mL
Compound: 18
Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay
Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay
[PMID: 11575946]
Molecular Weight

402.52

Formula

C24H34O5
CAS No.
SMILES

O[C@@]12[C@@]([C@@H](C(C=C3)=COC3=O)[C@H](C1)O)(CC[C@@]4([H])[C@@]2([H])CC[C@@]5([H])[C@@]4(CC[C@@H](C5)O)C)C
Structure Classification
Initial Source

蟾酥
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Desacetylbufotalin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desacetylbufotalin465-19-0Bufogenin B DeacetylbufotalinOthersBufadienolideChan'SuHeLacervical cancerInhibitorinhibitorinhibit

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