Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su

  • J Nat Prod. 2001 Sep;64(9):1148-52. doi: 10.1021/np0101088.
T Nogawa  1 ,  Y Kamano ,  A Yamashita ,  G R Pettit
Affiliations
  • 1. Faculty of Science, Kanagawa University, 2946 Tsuchiya, Hiratsuka, Kanagawa 259-1293, Japan.
PMID: 11575946 DOI: 10.1021/np0101088
Abstract

Five new bufadienolides, 3beta-formyloxyresibufogenin (1), 19-oxobufalin (2), 19-oxodesacetylcinobufagin (3), 6alpha-hydroxycinobufagin (4), and 1beta-hydroxybufalin (5), have been isolated together with the previously known bufadienolides 6-20 from the Chinese traditional drug "Ch'an Su". The structures were elucidated employing spectroscopic methods. Bufadienolides 1-5 provided significant inhibitory activity against the KB and HL-60 Cancer cell lines. In addition, bufadienolide 1 was found active against the MH-60 Cancer cell line.

Products