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Cat. No.: HY-N9981

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5β-Hydroxybufotalin

5β-Hydroxybufotalin (compound 6) is an anticancer agent that can effectively inhibit the growth activity of cancer cells. 5β-Hydroxybufotalin is also a natural product obtained from the chinese traditional drug Ch'an Su.

For research use only. We do not sell to patients.

CAS No.: 74531-99-0
Formula: C₂₆H₃₆O₇
Molecular Weight:460.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

5β-Hydroxybufotalin Chemical Structure

CAS No.: 74531-99-0

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	0.11 μg/mL Compound: 6	Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay	[PMID: 11575946]
DU-145	IC₅₀	0.024 μg/mL Compound: 6	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 11575946]
HL-60	IC₅₀	<0.01 μg/mL Compound: 6	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 11575946]
KB	IC₅₀	0.2 μg/mL Compound: 6	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 11575946]
KM-20L2	IC₅₀	0.034 μg/mL Compound: 6	Cytotoxicity against human KM20L2 cells after 72 hrs by MTT assay Cytotoxicity against human KM20L2 cells after 72 hrs by MTT assay	[PMID: 11575946]
MCF7	IC₅₀	0.046 μg/mL Compound: 6	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 11575946]
MH60	IC₅₀	>25 μg/mL Compound: 6	Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay	[PMID: 11575946]
NCI-H460	IC₅₀	0.048 μg/mL Compound: 6	Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay	[PMID: 11575946]
SF-268	IC₅₀	0.033 μg/mL Compound: 6	Cytotoxicity against human SF268 cells after 72 hrs by MTT assay Cytotoxicity against human SF268 cells after 72 hrs by MTT assay	[PMID: 11575946]

Chemical Information

CAS No. 74531-99-0
Molecular Weight 460.56
Formula C₂₆H₃₆O₇
SMILES

C[C@@]12[C@](C(C=C3)=COC3=O)([H])[C@H](C[C@@]1([C@@]4([H])[C@]([C@@]5([C@](CC4)(C[C@H](CC5)O)O)C)([H])CC2)O)OC(C)=O
Structure Classification
- Steroids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nogawa T, et al. Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su. J Nat Prod. 2001 Sep;64(9):1148-52. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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