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Art. -Nr.: HY-N13289

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12β-Hydroxyresibufogenin

12β-Hydroxyresibufogenin is a bufadienolide, which shows significant inhibitory activities against cancer cell lines.

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CAS. Nr.: 2042-58-2
Formel: C₂₄H₃₂O₅
Molecular Weight:400.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

12β-Hydroxyresibufogenin Chemical Structure

CAS. Nr.: 2042-58-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

12β-Hydroxyresibufogenin is a bufadienolide, which shows significant inhibitory activities against cancer cell lines^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	0.12 μg/mL Compound: 8	Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay Cytotoxicity against human BxPC3 cells after 72 hrs by MTT assay	[PMID: 11575946]
DU-145	IC₅₀	0.041 μg/mL Compound: 8	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 11575946]
HL-60	IC₅₀	0.045 μg/mL Compound: 8	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 11575946]
KB	IC₅₀	0.97 μg/mL Compound: 8	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 11575946]
KM-20L2	IC₅₀	0.012 μg/mL Compound: 8	Cytotoxicity against human KM20L2 cells after 72 hrs by MTT assay Cytotoxicity against human KM20L2 cells after 72 hrs by MTT assay	[PMID: 11575946]
MCF7	IC₅₀	0.066 μg/mL Compound: 8	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 11575946]
MH60	IC₅₀	>25 μg/mL Compound: 8	Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay Cytotoxicity against mouse MH60 cells after 72 hrs by MTT assay	[PMID: 11575946]
NCI-H460	IC₅₀	0.017 μg/mL Compound: 8	Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay Cytotoxicity against human NCI-H460 cells after 72 hrs by MTT assay	[PMID: 11575946]
SF-268	IC₅₀	0.046 μg/mL Compound: 8	Cytotoxicity against human SF268 cells after 72 hrs by MTT assay Cytotoxicity against human SF268 cells after 72 hrs by MTT assay	[PMID: 11575946]

Chemical Information

CAS. Nr. 2042-58-2
Molecular Weight 400.51
Formel C₂₄H₃₂O₅
SMILES

C[C@@]12[C@]3([C@](C[C@@H]2C(C=C4)=COC4=O)([H])O3)[C@@]5([H])[C@]([C@@]6([C@](C[C@H](CC6)O)([H])CC5)C)([H])C[C@H]1O
Structure Classification
- Steroids
Initial Source
- Animals
Ch’an Su
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nogawa T, et al. Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su. J Nat Prod. 2001 Sep;64(9):1148-52. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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