One new bufadienolide from Chinese drug "Chan'Su"

  • J Asian Nat Prod Res. 2008 Mar-Apr;10(3-4):233-7. doi: 10.1080/10286020701604839.
Li Qiao  1 ,  Yong-Fu Huang ,  Jia-Qing Cao ,  Yu-Zhi Zhou ,  Xiu-Lan Qi ,  Yue-Hu Pei
Affiliations
  • 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
PMID: 18335338 DOI: 10.1080/10286020701604839
Abstract

A new bufadienolide named 16beta-acetoxy-bufarenogin (1), together with six known bufadienolides, namely, 11alpha,12beta-dihydroxy-bufalin (2), bufotalin (3), hellebrigenin (4), desacetylbufotalin (5), gamabufotalin (6), and resibufagin (7) were isolated from Chan'Su. Of these, 2 was a new natural product. Their structures were elucidated by spectral methods. The cytotoxic activities in vitro of these compounds have been assayed against HeLa cell line. They all showed strong cytotoxic activities.

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