2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. c-Met-IN-21

c-Met-IN-21 (compound 54) is a c-met inhibitor with an IC50 value of 0.45? nM, and shows anti-tumor efficacy in vivo.

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c-Met-IN-21

c-Met-IN-21 화학구조

CAS No. : 3025958-01-1

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c-Met-IN-21 Related Antibodies

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제품 설명

c-Met-IN-21 (compound 54) is a c-met inhibitor with an IC50 value of 0.45? nM, and shows anti-tumor efficacy in vivo[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
>20 μM
Compound: 54
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38086189]
L02 IC50
>20 μM
Compound: 54
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38086189]
MHCC97H IC50
1.03 nM
Compound: 54
Antiproliferative activity against human MHCC97H cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MHCC97H cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38086189]
분자량

610.66

화학식

C33H32F2N8O2
CAS No.
SMILES

FC(F)(C1=NN=C2C=CC(C(C=C3CC4)=CC=C3N(CC(N5CCN(C(C)C)CC5)=O)C4=O)=NN12)C6=CC=C7C(C=CC=N7)=C6
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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c-Met-IN-21 Related Classifications

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Keywords:

c-Met-IN-213025958-01-1c-Met/HGFRHepatocellular carcinomaSelectivityStructural optimizationc-Met inhibitorInhibitorinhibitorinhibit

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상품명:
c-Met-IN-21
Cat. No.:
HY-157302
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