Chloroethene (polymer)  (Synonyms: Polyvinyl chloride)

Chloroethene polymer (Polyvinyl chloride) is an orally active vinyl chloride polymer. Chloroethene polymer is cytotoxic, reproductively toxic, and an endocrine disruptor. Chloroethene polymer can be used in the research of packaging inner surfaces, food wrapping paper, agricultural crop coverings, and plastic bottles^{[1][2][3][4][5][6][7]}.

Polyvinyl chloride (120-140 nm; 25-200 μg/mL; 24-72 h) NPs induces cytotoxicity in normal human lung fibroblast cells (IMR 90)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polyvinyl chloride (100-500 mg/kg; p.o.; 60 days) causes reproductive toxicity in male Wistar rats^[4].
Polyvinyl chloride (50-100 mg/kg; p.o.; daily) disrupts activin hormone levels, reducing testes weight and sperm count in male offspring and increasing activin in female offspring of mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

20000-80000

(C₂H₃Cl)x

9002-86-2

Solid

White to off-white

ClC=C.[x]

Room temperature in continental US; may vary elsewhere.

• [1]. Emma Popek. Chapter 2 - Environmental Chemical Pollutants. Sampling and Analysis of Environmental Chemical Pollutants (Second Edition). A Complete Guide 2018, Pages 13-69.

  [2]. Jaakkola JJ, et al. The role of exposure to phthalates from polyvinyl chloride products in the development of asthma and allergies: a systematic review and meta-analysis. Environ Health Perspect. 2008 Jul;116(7):845-53.  [Content Brief]

  [3]. Mahadevan G, et al. Comparison of Genotoxicity and Cytotoxicity of Polyvinyl Chloride and Poly(methyl methacrylate) Nanoparticles on Normal Human Lung Cell Lines. Chem Res Toxicol. 2021 Jun 21;34(6):1468-1480.  [Content Brief]

  [4]. Zhao GQ, et al. In vitro model of bacterial biofilm formation on polyvinyl chloride biomaterial. Cell Biochem Biophys. 2011 Nov;61(2):371-6.  [Content Brief]

  [5]. Zhuang J, et al. Combined exposure to polyvinyl chloride and polystyrene microplastics induces liver injury and perturbs gut microbial and serum metabolic homeostasis in mice. Ecotoxicol Environ Saf. 2023 Nov 15;267:115637.  [Content Brief]

  [6]. Archana D, et al. Alleviative effect of resveratrol on polyvinyl chloride-induced reproductive toxicity in male Wistar rats. Food Chem Toxicol. 2018 Jun;116(Pt B):173-181.  [Content Brief]

  [7]. AL-Farhaan M B G. Effect Of Polyvinyl Chloride On Activin Hormone In Mice.