2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. µ-Conotoxin-CnIIIC acetate

µ-Conotoxin-CnIIIC acetate, a 22-residue conopeptide, is a potent antagonist of the voltage-gated NaV1.4 sodium channel with an IC50 of 1.3 nM acting at the neuromuscular junction. µ-Conotoxin-CnIIIC acetate has myorelaxant and analgesic effects.

For research use only. We do not sell to patients.

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µ-Conotoxin-CnIIIC acetate Chemical Structure

µ-Conotoxin-CnIIIC acetate Chemical Structure

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Based on 1 publication(s) in Google Scholar

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µ-Conotoxin-CnIIIC acetate Related Antibodies

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Description

µ-Conotoxin-CnIIIC acetate, a 22-residue conopeptide, is a potent antagonist of the voltage-gated NaV1.4 sodium channel with an IC50 of 1.3 nM acting at the neuromuscular junction. µ-Conotoxin-CnIIIC acetate has myorelaxant and analgesic effects[1].

IC50 & Target[1]

Nav1.4

1.3 nM (IC50)

Molecular Weight

2375.70 (free base)

Formula

C92H139N35O28S6.xC2H4O2
Appearance

Solid

Color

White to off-white

Sequence

{Glp}-Gly-Cys-Cys-Asn-Gly-Pro-Lys-Gly-Cys-Ser-Ser-Lys-Trp-Cys-Arg-Asp-His-Ala-Arg-Cys-Cys-NH2 (Disulfide bridge: Cys3-Cys15, Cys4-Cys21, Cys10-Cys22)
Sequence Shortening

{Glp}-GCCNGPKGCSSKWCRDHARCC-NH2 (Disulfide bridge: Cys3-Cys15, Cys4-Cys21, Cys10-Cys22)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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This equation is commonly abbreviated as: C1V1 = C2V2

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
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µ-Conotoxin-CnIIIC acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

µ-Conotoxin-CnIIICSodium ChannelNa channelsNa+ channelsNaV1.4 sodium channelconopeptidemyorelaxantanalgesicInhibitorinhibitorinhibit

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