Cystathionine-γ-lyase-IN-1

Name: Cystathionine-γ-lyase-IN-1
Brand: MedChemExpress
SKU: HY-136211
Rating: 4.5 (0 reviews)

Cat. No.: HY-136211 Pureza: 98.90%: Ficha de datos
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Cystathionine-γ-lyase-IN-1 is a selective cystathionine γ-lyase (CSE) enzyme inhibitor with an IC₅₀ of 6.3 μM. Cystathionine-γ-lyase-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Cystathionine-γ-lyase-IN-1 Estructura química

No. CAS : 2165706-30-7

Tamaño	Stock	Cantidad

Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Descripciòn

Cystathionine-γ-lyase-IN-1 is a selective cystathionine γ-lyase (CSE) enzyme inhibitor with an IC₅₀ of 6.3 μM^[1]. Cystathionine-γ-lyase-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

IC50: 6.3 μM (CSE)^[1]

In Vitro

Cystathionine-γ-lyase-IN-1 (compound 2a) completely abrogates L-cysteine-induced vasorelaxation at a concentration of 100 μM^[1].
Cystathionine-γ-lyase-IN-1 (100 μM; 30 minutes) significantly inhibits the increased H2S production stimulated by L-Cys in mouse aorta homogenates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

184.22

Fòrmula

C₇H₈N₂O₂S

No. CAS

2165706-30-7

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1NC(SC1)=O)NCC#C

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 18 mg/mL (97.71 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 9 mg/mL (48.85 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.4283 mL	27.1415 mL	54.2829 mL
5 mM	1.0857 mL	5.4283 mL	10.8566 mL
10 mM	0.5428 mL	2.7141 mL	5.4283 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: ≥99.0%

Select Batch:

Ficha de datos (271 KB) SDS (252 KB)

COA (247 KB) Elemental Analysis Report (105 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Angela Corvino, et al. Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production. Sci Rep. 2016 Oct 6;6:34398. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO	1 mM	5.4283 mL	27.1415 mL	54.2829 mL	135.7073 mL
	5 mM	1.0857 mL	5.4283 mL	10.8566 mL	27.1415 mL
	10 mM	0.5428 mL	2.7141 mL	5.4283 mL	13.5707 mL
	15 mM	0.3619 mL	1.8094 mL	3.6189 mL	9.0472 mL
	20 mM	0.2714 mL	1.3571 mL	2.7141 mL	6.7854 mL
	25 mM	0.2171 mL	1.0857 mL	2.1713 mL	5.4283 mL
	30 mM	0.1809 mL	0.9047 mL	1.8094 mL	4.5236 mL
	40 mM	0.1357 mL	0.6785 mL	1.3571 mL	3.3927 mL
DMSO	50 mM	0.1086 mL	0.5428 mL	1.0857 mL	2.7141 mL
	60 mM	0.0905 mL	0.4524 mL	0.9047 mL	2.2618 mL
	80 mM	0.0679 mL	0.3393 mL	0.6785 mL	1.6963 mL