(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin

Cat. No.: HY-P2014: Data Sheet Handling Instructions
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(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin is an oxytocin antagonist and can be used for the research of sexual behavior.

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(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin 화학구조

CAS No. : 114056-26-7

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

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This product is a controlled substance and not for sale in your territory.

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•Related Small Molecules:

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin is an oxytocin antagonist and can be used for the research of sexual behavior^[1].

IC₅₀ & Target

Oxytocin^[1]

In Vivo

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin (50-1000 ng; Intra-MPOA; 1 μL) inhibits certain aspects of male sexual behavior in rats^[1].
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin (100 ng; i.c.v.; 1 μL) effectively suppresses hypoalgesia following copulatory behavior in male rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult Long–Evans/Blue-Spruce rats^[1]
Dosage:	50 ng, 200 ng, and 1 μg
Administration:	Intra-MPOA (medial preoptic area) injection, 1 μL
Result:	Significantly increased intromission latency and anogenital investigation at 1 μg dose. Significantly decreased intromission ratio (2) at all doses.

Animal Model:	Adult male and female Long-Evans rats (8 weeks old, 220–260 g BW)^[2]
Dosage:	100 ng
Administration:	Intracerebroventricular injection, 1 μL
Result:	Was effective in reducing pain threshold heightened by copulatory behavior.

분자량

1154.40

화학식

C₅₄H₇₉N₁₁O₁₃S₂

CAS No.

114056-26-7

Sequence

Mpa(Cy)-Tyr(Me)-Ile-Thr-Asn-Cys-Pro-{Orn}-Tyr-NH2 (disulfide bridge:Mpa1-Cys6)

Sequence Shortening

Mpa(Cy)-Tyr(Me)-ITNCP-{Orn}-Y-NH2 (disulfide bridge:Mpa1-Cys6)

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

용액&용해도

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Gil M, et al. Oxytocin in the medial preoptic area facilitates male sexual behavior in the rat. Horm Behav. 2011 Apr;59(4):435-43. [Content Brief]

[2]. Futagami H, et al. Oxytocin mediates copulation-induced hypoalgesia of male rats. Neurosci Lett. 2016 Apr 8;618:122-126. [Content Brief]