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  4. Drometrizole

Drometrizole  (Synonyms: 2-(2-ヒドロキシ-5-メチルフェニル)ベンゾトリアゾール)

製品番号: HY-131551 純度: 99.81%
COA 取扱説明書 Technical Support

Drometrizole is an orally active UV absorber and can be used in cosmetic research. Drometrizole has low acute toxicity, no teratogenicity and carcinogenicity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Drometrizole

Drometrizole 構造式

CAS 番号 : 2440-22-4

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 在庫あり
Solution
10 mM * 1 mL in DMSO USD 66 在庫あり
Solid
25 g $60 在庫あり
50 g $90 在庫あり
100 g $125 在庫あり
> 100 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of Drometrizole:

Drometrizole 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Drometrizole is an orally active UV absorber and can be used in cosmetic research. Drometrizole has low acute toxicity, no teratogenicity and carcinogenicity[1][2].

体内実験

Drometrizole exhibits oral bioavailability of 94.3% (30 mg/kg) and 2.13% (300 mg/kg) in male rats after a single oral administration[1].
Pharmacokinetic Analysis in Male Rats[1]

Route Dose (mg/kg) Tmax (h) Cmax (ng/mL) Half-life (h) AUC (h·ng/mL)
i.v. 2.25 / 4510 84.8 10500
i.g. 30 0.0196 138 1120 132000
i.g. 300 0.266 358 103 29800

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

225.25

分子式

C13H11N3O
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(C)C=C1N2N=C3C(C=CC=C3)=N2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

RT, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (RT, stored under nitrogen)
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (221.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4395 mL 22.1976 mL 44.3951 mL
5 mM 0.8879 mL 4.4395 mL 8.8790 mL
10 mM 0.4440 mL 2.2198 mL 4.4395 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (11.10 mM); Suspended solution

    This protocol yields a suspended solution of ≥ 2.5 mg/mL (saturation unknown). Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.81%

COA (251 KB) HNMR (121 KB) RP-HPLC (94 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4395 mL 22.1976 mL 44.3951 mL 110.9878 mL
5 mM 0.8879 mL 4.4395 mL 8.8790 mL 22.1976 mL
10 mM 0.4440 mL 2.2198 mL 4.4395 mL 11.0988 mL
15 mM 0.2960 mL 1.4798 mL 2.9597 mL 7.3992 mL
20 mM 0.2220 mL 1.1099 mL 2.2198 mL 5.5494 mL
25 mM 0.1776 mL 0.8879 mL 1.7758 mL 4.4395 mL
30 mM 0.1480 mL 0.7399 mL 1.4798 mL 3.6996 mL
40 mM 0.1110 mL 0.5549 mL 1.1099 mL 2.7747 mL
50 mM 0.0888 mL 0.4440 mL 0.8879 mL 2.2198 mL
60 mM 0.0740 mL 0.3700 mL 0.7399 mL 1.8498 mL
80 mM 0.0555 mL 0.2775 mL 0.5549 mL 1.3873 mL
100 mM 0.0444 mL 0.2220 mL 0.4440 mL 1.1099 mL
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Drometrizole Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Drometrizole2440-22-4Biochemical Assay ReagentsEnvironmental PollutantsEnvironmental Contaminantscosmetic ingredientultraviolet light absorberInhibitorinhibitorinhibit

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