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  3. Endocrine and Metabolic Disease Models Bacterial Antibiotic
  4. High Uric Acid Models
  5. Ethambutol

Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.

For research use only. We do not sell to patients.

Ethambutol Chemical Structure

Ethambutol Chemical Structure

CAS No. : 74-55-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 44 In-stock
Solution
10 mM * 1 mL in DMSO USD 44 In-stock
Solid
5 mg USD 40 In-stock
10 mg USD 68 In-stock
25 mg USD 136 In-stock
50 mg USD 225 In-stock
100 mg USD 380 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ethambutol:

Ethambutol Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Ethambutol

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Description

Ethambutol is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases. Target: Antibacterial Ethambutol directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. In M. smegmatis, Ethambutol inhibits synthesis of arabinan completely and inhibits AG synthesis most likely as a consequence of this; more than 50% of the cell arabinan is released from the bacteria following Ethambutol treatment, whereas no galactan is released. Ethambutol main targets against embB gene product in M. avium. Ethambutol induces 60% changes in the embB gene in M. tuberculosis resistant mutants [1]. Ethambutol is effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. Nearly all strains of M. tuberculosis and M. kansasii as well as a number of strains of the M. aviumcomplex (MAC) are sensitive to Ethambutol. [1] Ethambutol is potency against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro [2]. Ethambutol is efficient on treatment of mycobacterial-infected macrophages. When M. tuberculosis infected macrophages are treated with 6 μg/mL Ethambutol, the log CFUs following treatment for 3 days is 4.17, while value in control group is 4.8. The MICs for M. avium (MTCC 1723) and M. smegmatis (MTCC 6) are 15 μg/mL and 0.18 μg/mL, respectively. Ethambutol is efficient in animal model. 100 mg/kg Ethambutol given orally 15 days post i.v. infection 1 ×/week for 5 weeks, induces a lower log CFU compared with untreatment (4.59 vs 5.07) [3].

In Vivo

Induction of Hyperuricaemic Disease[4][5]

Background
Elevated uric acid levels can lead to crystal deposition and may cause gout, urolithiasis, and urate nephropathy. Ethambutol can cause increased uric acid levels by reducing renal uric acid clearance, ultimately leading to hyperuricemia[4][5].
Specific Mmodeling Methods
Rat[4]: male • Wistar rats • SPF • 200-220 g
Administrtion: 250 mg/kg • intragastric administration • once daily for 23 days
Note
Modeling Record
Pathological changes: Pathological damage and inflammatory reaction in the thymus and spleen; thymus atrophy, cortical medullary fusion; splenic sinus congestion, with iron yellow deposition.
Physiological changes: serum uric acid level ↑; sparse cells, increased number of tissue cells, and decreased number of lymphocytes.
Molecular changes: URAT1 level ↑, OAT1 level ↓ in kidney homogenate.
Correlated Product(s): Xanthine Oxidase Inhibitors

Induction of Optic Neuropathy[6]

Background
Ethambutol treatment can cause binocular toxicity at certain doses and durations. There is currently no clear treatment to prevent damage to retinal neuronal cells in cases of ethhambutol-induced optic neuropathy (EON).
Specific Mmodeling Methods
Rat[6]: Wistar rats • Administration: 35 mg/kg/day &bull po for 30 days
Note
Modeling Record
Molecular changes: Bcl-2, Caspase-3 expression levels ↑.
Pathological indicators: Ganglion cell damage, increased density of retinal ganglion cells (RGC); RGC cell layer thickened due to vacuoles formed in the ganglion cell cytoplasm.
Correlated Product(s): Citicoline (HY-B0739)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

204.31

Formula

C10H24N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC[C@H](NCCN[C@@H](CC)CO)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (489.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8945 mL 24.4726 mL 48.9452 mL
5 mM 0.9789 mL 4.8945 mL 9.7890 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8945 mL 24.4726 mL 48.9452 mL 122.3631 mL
5 mM 0.9789 mL 4.8945 mL 9.7890 mL 24.4726 mL
10 mM 0.4895 mL 2.4473 mL 4.8945 mL 12.2363 mL
15 mM 0.3263 mL 1.6315 mL 3.2630 mL 8.1575 mL
20 mM 0.2447 mL 1.2236 mL 2.4473 mL 6.1182 mL
25 mM 0.1958 mL 0.9789 mL 1.9578 mL 4.8945 mL
30 mM 0.1632 mL 0.8158 mL 1.6315 mL 4.0788 mL
40 mM 0.1224 mL 0.6118 mL 1.2236 mL 3.0591 mL
50 mM 0.0979 mL 0.4895 mL 0.9789 mL 2.4473 mL
60 mM 0.0816 mL 0.4079 mL 0.8158 mL 2.0394 mL
80 mM 0.0612 mL 0.3059 mL 0.6118 mL 1.5295 mL
100 mM 0.0489 mL 0.2447 mL 0.4895 mL 1.2236 mL
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Ethambutol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethambutol74-55-5BacterialAntibioticInhibitorinhibitorinhibit

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