1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Ethambutol dihydrochloride

Ethambutol dihydrochloride (Synonyms: Emb dihydrochloride)

Cat. No.: HY-B0535A Purity: ≥98.0%
Handling Instructions

Ethambutol dihydrochloride (Emb dihydrochloride) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.

For research use only. We do not sell to patients.

Ethambutol dihydrochloride Chemical Structure

Ethambutol dihydrochloride Chemical Structure

CAS No. : 1070-11-7

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Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
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ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
500 mg USD 55 In-stock
Estimated Time of Arrival: December 31
1 g USD 66 In-stock
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5 g USD 119 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ethambutol dihydrochloride:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Ethambutol dihydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ethambutol dihydrochloride (Emb dihydrochloride) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases. Target: Antibacterial Ethambutol dihydrochloride (Emb dihydrochloride) directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. In M. smegmatis, Ethambutol inhibits synthesis of arabinan completely and inhibits AG synthesis most likely as a consequence of this; more than 50% of the cell arabinan is released from the bacteria following Ethambutol treatment, whereas no galactan is released. Ethambutol main targets against embB gene product in M. avium. Ethambutol induces 60% changes in the embB gene in M. tuberculosis resistant mutants [1]. Ethambutol dihydrochloride (Emb dihydrochloride) is effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. Nearly all strains of M. tuberculosis and M. kansasii as well as a number of strains of the M. aviumcomplex (MAC) are sensitive to Ethambutol. [1] Ethambutol dihydrochloride (Emb dihydrochloride) is potency against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro [2]. Ethambutol is efficient on treatment of mycobacterial-infected macrophages. When M. tuberculosis infected macrophages are treated with 6 μg/mL Ethambutol, the log CFUs following treatment for 3 days is 4.17, while value in control group is 4.8. The MICs for M. avium (MTCC 1723) and M. smegmatis (MTCC 6) are 15 μg/mL and 0.18 μg/mL, respectively. Ethambutol is efficient in animal model. 100 mg/kg Ethambutol given orally 15 days post i.v. infection 1 ×/week for 5 weeks, induces a lower log CFU compared with untreatment (4.59 vs 5.07) [3].

Clinical Trial
Molecular Weight

277.23

Formula

C10H26Cl2N2O2

CAS No.
SMILES

CC[[email protected]](NCCN[[email protected]@H](CC)CO)CO.Cl.Cl

Structure Classification
Source

Mycobacterium smegmatis

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (360.71 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (180.36 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6071 mL 18.0356 mL 36.0711 mL
5 mM 0.7214 mL 3.6071 mL 7.2142 mL
10 mM 0.3607 mL 1.8036 mL 3.6071 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (360.71 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
Ethambutol dihydrochloride
Cat. No.:
HY-B0535A
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