1. Anti-infection
  2. Bacterial
  3. Delamanid

Delamanid (Synonyms: OPC-67683)

Cat. No.: HY-10846 Purity: 99.73%
Handling Instructions

Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex.

For research use only. We do not sell to patients.

Delamanid Chemical Structure

Delamanid Chemical Structure

CAS No. : 681492-22-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
2 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
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10 mg USD 114 In-stock
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25 mg USD 180 In-stock
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50 mg USD 312 In-stock
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100 mg USD 540 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex. In vitro: inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex.[1] In in-vitro studies, delamanid shows more potent antibacterial activity against drug-susceptible and drug-resistant strains of M. tuberculosis.[2] Delamanid do not affect rifampin, pyrazinamide, and isoniazid exposure; the ethambutol AUCτ and Cmax values are about 25% higher with delamanid coadministration. [3] In vivo: Twice-daily oral dosing of delamanid at 30 mg kg-1 for 5 days resulted in sterile cures in a mouse model of VL. [4]

Clinical Trial
Molecular Weight

534.48

Formula

C₂₅H₂₅F₃N₄O₆

CAS No.

681492-22-8

SMILES

FC(F)(F)OC1=CC=C(OC2CCN(C3=CC=C(OC[[email protected]@]4(C)CN5C(O4)=NC([N+]([O-])=O)=C5)C=C3)CC2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (93.55 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8710 mL 9.3549 mL 18.7098 mL
5 mM 0.3742 mL 1.8710 mL 3.7420 mL
10 mM 0.1871 mL 0.9355 mL 1.8710 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (4.68 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.68 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.73%

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Delamanid
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HY-10846
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