Delamanid (Synonyms: OPC-67683)

Name: Delamanid
Brand: MedChemExpress
SKU: HY-10846
Rating: 5.0 (8 reviews)

Cat. No.: HY-10846 Purity: 99.95%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids.

For research use only. We do not sell to patients.

CAS No. : 681492-22-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
2 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Delamanid:

8 Publications Citing Use of MCE Delamanid

Microbiological Assay

Cell Proliferation/Viability Assay

ELISA

Bio/Physico-chemical Assay

: Delamanid purchased from MedChemExpress. Usage Cited in: Drug Dev Ind Pharm. 2025 Jul 24:1-16. [Abstract]; Effect of pure Delamanid (0-10μg/mL) and selected delamanid-loaded microemulsion formulation on cell viability of a549 (a),ncI-h358 (B) cell line using mtt assay treated with various concentrations after 24 h.

: Delamanid purchased from MedChemExpress. Usage Cited in: Drug Dev Ind Pharm. 2025 Jul 24:1-16. [Abstract]; Delamanid (0.125, 0.25, 0.5, 1, 2 μg/mL;24 h) showed no effect in levels of inflammatory cytokines;Il-1β (a), Il-6 (B) produced after expo-sure to nr8383 cells.

: Delamanid purchased from MedChemExpress. Usage Cited in: Drug Dev Ind Pharm. 2025 Jul 24:1-16. [Abstract]; Delamanid (0.125, 0.25, 0.5, 1, 2 μg/mL;24 h) showed no effect in lnitric oxide (NO) concentration to nr8383 cells.

: Delamanid purchased from MedChemExpress. Usage Cited in: Drug Dev Ind Pharm. 2025 Jul 24:1-16. [Abstract]; The viability was compared among M. bovis samples treated with Delamanid (0.156, 0.313, 0.625, 1.25, 2.5, 5 μg/mL) at varying concentrations.

: Delamanid purchased from MedChemExpress. Usage Cited in: Dis Model Mech. 2021 Dec 1;14(12):dmm049145. [Abstract]; Delamanid (10 μM) resulted in a significant reduction of the bacterial signal in M. marinum-tdTomato yolk-infected zebrafish embryos.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	107.5 μg/mL Compound: Delamanid	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 26487912]
MRC5	IC₅₀	0.43 μM Compound: 5; OPC-67683	Antitrypanosomal activity against Trypanosoma cruzi infected in human MRC5 cells assessed as parasite growth inhibition incubated for 7 days by chlorophenol red alpha-D-galactopyranoside-based assay Antitrypanosomal activity against Trypanosoma cruzi infected in human MRC5 cells assessed as parasite growth inhibition incubated for 7 days by chlorophenol red alpha-D-galactopyranoside-based assay	[PMID: 26901446]
MRC5	IC₅₀	> 64 μM Compound: 5; OPC-67683	Cytotoxicity against human MRC5 cells assessed as cell viability incubated for 72 hrs by fluorimetric assay Cytotoxicity against human MRC5 cells assessed as cell viability incubated for 72 hrs by fluorimetric assay	[PMID: 26901446]
Vero	CC₅₀	> 32 μg/mL Compound: Delamanid	Cytotoxicity against African green monkey vero cells assessed as reduction in cell viability Cytotoxicity against African green monkey vero cells assessed as reduction in cell viability	[PMID: 35777718]

In Vitro

Delamanid inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex^[1].
Delamanid shows more potent antibacterial activity against drug-susceptible and drug-resistant strains of M. tuberculosis^[2].
Delamanid do not affect rifampin, pyrazinamide, and isoniazid exposure; the ethambutol AUCτ and Cmax values are about 25% higher with delamanid coadministration^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Delamanid (orally administration; 30 mg/kg; 5 days) results in sterile cures in a mouse model of VL^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

534.48

Formula

C₂₅H₂₅F₃N₄O₆

CAS No.

681492-22-8

Appearance

Solid

Color

Off-white to yellow

SMILES

FC(F)(F)OC1=CC=C(OC2CCN(C3=CC=C(OC[C@@]4(C)CN5C(O4)=NC([N+]([O-])=O)=C5)C=C3)CC2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (37.42 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 2 mg/mL (3.74 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8710 mL	9.3549 mL	18.7098 mL
5 mM	0.3742 mL	1.8710 mL	3.7420 mL
10 mM	0.1871 mL	0.9355 mL	1.8710 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (271 KB) SDS (419 KB)

COA (245 KB) HNMR (292 KB) RP-HPLC (243 KB) LCMS (94 KB) OR (250 KB)

Handling Instructions (2659 KB)

References

[1]. Sotgiu G et al. Delamanid (OPC-67683) for treatment of multi-drug-resistant tuberculosis. Expert Rev Anti Infect Ther. 2015 Mar;13(3):305-15. [Content Brief]

[2]. Xavier AS et al. Delamanid: A new armor in combating drug-resistant tuberculosis. J Pharmacol Pharmacother. 2014 Jul;5(3):222-4 [Content Brief]

[3]. Mallikaarjun S et al. Delamanid Coadministered with Antiretroviral Drugs or Antituberculosis Drugs Shows No Clinically Relevant Drug-Drug Interactions in Healthy Subjects. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5976-85. [Content Brief]

[4]. Patterson S et al.The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis. Elife. 2016 May 24;5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol / DMSO	1 mM	1.8710 mL	9.3549 mL	18.7098 mL	46.7744 mL
DMSO	5 mM	0.3742 mL	1.8710 mL	3.7420 mL	9.3549 mL
	10 mM	0.1871 mL	0.9355 mL	1.8710 mL	4.6774 mL
	15 mM	0.1247 mL	0.6237 mL	1.2473 mL	3.1183 mL
	20 mM	0.0935 mL	0.4677 mL	0.9355 mL	2.3387 mL
	25 mM	0.0748 mL	0.3742 mL	0.7484 mL	1.8710 mL
	30 mM	0.0624 mL	0.3118 mL	0.6237 mL	1.5591 mL

Delamanid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Delamanid681492-22-8OPC-67683OPC67683OPC 67683BacterialAntibioticInhibitorinhibitorinhibit

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Delamanid (Synonyms: OPC-67683)

Customer Review

Other Forms of Delamanid:

Delamanid Related Antibodies

8 Publications Citing Use of MCE Delamanid

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Delamanid Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Delamanid Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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