1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Delamanid

Delamanid (Synonyms: OPC-67683)

Cat. No.: HY-10846 Purity: 99.80%
Handling Instructions

Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids.

For research use only. We do not sell to patients.

Delamanid Chemical Structure

Delamanid Chemical Structure

CAS No. : 681492-22-8

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10 mM * 1  mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
2 mg USD 60 In-stock
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5 mg USD 84 In-stock
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10 mg USD 114 In-stock
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25 mg USD 180 In-stock
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50 mg USD 312 In-stock
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100 mg USD 540 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids[1].

In Vitro

Delamanid inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex[1].
Delamanid shows more potent antibacterial activity against drug-susceptible and drug-resistant strains of M. tuberculosis[2].
Delamanid do not affect rifampin, pyrazinamide, and isoniazid exposure; the ethambutol AUCτ and Cmax values are about 25% higher with delamanid coadministration[3].

In Vivo

Delamanid (orally administration; 30 mg/kg; 5 days) results in sterile cures in a mouse model of VL[4].

Clinical Trial
Molecular Weight

534.48

Formula

C₂₅H₂₅F₃N₄O₆

CAS No.

681492-22-8

SMILES

FC(F)(F)OC1=CC=C(OC2CCN(C3=CC=C(OC[[email protected]@]4(C)CN5C(O4)=NC([N+]([O-])=O)=C5)C=C3)CC2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (93.55 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8710 mL 9.3549 mL 18.7098 mL
5 mM 0.3742 mL 1.8710 mL 3.7420 mL
10 mM 0.1871 mL 0.9355 mL 1.8710 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (4.68 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.68 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.80%

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Keywords:

DelamanidOPC-67683OPC67683OPC 67683BacterialAntibioticInhibitorinhibitorinhibit

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