1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Linezolid

Linezolid (Synonyms: PNU-100766)

Cat. No.: HY-10394 Purity: 99.78%
Handling Instructions

Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics.

For research use only. We do not sell to patients.

Linezolid Chemical Structure

Linezolid Chemical Structure

CAS No. : 165800-03-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 120 In-stock
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100 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 8 publication(s) in Google Scholar

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Description

Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics[1][2][3].

In Vitro

Linezolid (PNU-100766) prevents the synthesis of bacterial protein via binding to rRNA on both the 30S and 50S ribosomal subunits[3].

Clinical Trial
Molecular Weight

337.35

Formula

C₁₆H₂₀FN₃O₄

CAS No.

165800-03-3

SMILES

O=C(O[[email protected]]1CNC(C)=O)N(C1)C2=CC(F)=C(N3CCOCC3)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (296.43 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9643 mL 14.8214 mL 29.6428 mL
5 mM 0.5929 mL 2.9643 mL 5.9286 mL
10 mM 0.2964 mL 1.4821 mL 2.9643 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.41 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.78%

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Keywords:

LinezolidPNU-100766PNU100766PNU 100766BacterialAntibioticInhibitorinhibitorinhibit

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