The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class

  • Bioorg Med Chem Lett. 2002 Aug 19;12(16):2121-3. doi: 10.1016/s0960-894x(02)00352-9.
Richard J Sciotti  1 ,  Marina Pliushchev ,  Paul E Wiedeman ,  Darlene Balli ,  Robert Flamm ,  Angela M Nilius ,  Kennan Marsh ,  DeAnne Stolarik ,  Robert Jolly ,  Roger Ulrich ,  Stevan W Djuric
Affiliations
  • 1. Abbott Laboratories, Infectious Disease Research, Department 47N, Abbott Park, IL 60064, USA. [email protected]
PMID: 12127518 DOI: 10.1016/s0960-894x(02)00352-9
Abstract

A novel series of antimicrobials of the Oxazolidinone class is disclosed. These compounds are characterized relative to previously described analogues by a 'halostilbene-derived' pharmacophore and demonstrate enhanced antimicrobial activity against key Gram-positive pathogens when compared to Linezolid.