Fmoc-NH-PEG12-CH2CH2COOH

Name: Fmoc-NH-PEG12-CH2CH2COOH
Brand: MedChemExpress
SKU: HY-135821
Rating: 4.5 (0 reviews)

Cat. No.: HY-135821 Purity: 99.96%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Fmoc-NH-PEG12-CH2CH2COOH 화학구조

CAS No. : 1952360-91-6

사이즈	재고	수량
250 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	해외재고보유	Estimated Time of Arrival: December 31
25 g	해외재고보유	Estimated Time of Arrival: December 31
100 g	해외재고보유	Estimated Time of Arrival: December 31
> 100 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

839.97

화학식

C₄₂H₆₅NO₁₆

CAS No.

1952360-91-6

Appearance

Liquid (Density: 1.175±0.06 g/cm³)

Color

Light yellow to light brown

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : ≥ 100 mg/mL (119.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1905 mL	5.9526 mL	11.9052 mL
5 mM	0.2381 mL	1.1905 mL	2.3810 mL
10 mM	0.1191 mL	0.5953 mL	1.1905 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.96%

Select Batch:

Data Sheet (265 KB) SDS (393 KB)

COA (239 KB) HNMR (134 KB) RP-HPLC (241 KB) LCMS (327 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1905 mL	5.9526 mL	11.9052 mL	29.7630 mL
	5 mM	0.2381 mL	1.1905 mL	2.3810 mL	5.9526 mL
	10 mM	0.1191 mL	0.5953 mL	1.1905 mL	2.9763 mL
	15 mM	0.0794 mL	0.3968 mL	0.7937 mL	1.9842 mL
	20 mM	0.0595 mL	0.2976 mL	0.5953 mL	1.4881 mL
	25 mM	0.0476 mL	0.2381 mL	0.4762 mL	1.1905 mL
	30 mM	0.0397 mL	0.1984 mL	0.3968 mL	0.9921 mL
	40 mM	0.0298 mL	0.1488 mL	0.2976 mL	0.7441 mL
	50 mM	0.0238 mL	0.1191 mL	0.2381 mL	0.5953 mL
	60 mM	0.0198 mL	0.0992 mL	0.1984 mL	0.4960 mL
	80 mM	0.0149 mL	0.0744 mL	0.1488 mL	0.3720 mL
	100 mM	0.0119 mL	0.0595 mL	0.1191 mL	0.2976 mL