Gabazine free base (Synonyms: SR95531 free base)

製品番号: HY-117256: Data Sheet 取扱説明書
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Gabazine is a selective and competitive antagonist of GABA_A receptor, with an IC₅₀ of 0.2 μM for GABA receptor.

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CAS 番号 : 105538-73-6

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Other 在庫あり Forms of Gabazine free base:

Gabazine

Other Forms of Gabazine free base:

Gabazine 在庫あり

顧客検証

Bio/Physico-chemical Assay

In Vivo Efficacy Study

: Gabazine free base purchased from MedChemExpress. Usage Cited in: Nature. 2025 Oct;646(8087):1243-1253. [Abstract]; A small fraction of the currents remained in two cells, after d-AP5 exposure, presented a shape consistent with GABAA receptor-mediated currents and could be inhibited with the GABAA receptor blocker Gabazine (Gbz) (12.5 μM).

: Gabazine free base purchased from MedChemExpress. Usage Cited in: Elife. 2024 May 29.; The effects of ICV injection of different doses of Gabazine (2 or 4 μg/mL; 2000 nL) on the recovery time of midazolam. Compared with the vehicle, ICV injection of Gabazine could reduce the recovery time.

: Gabazine free base purchased from MedChemExpress. Usage Cited in: Elife. 2024 May 29.; The peak ΔF/F in the Before RORR and RORR-Recovery stages with or without intracerebroventricular injection of Gabazine (4 μg/mL). Gabazine could increase the ΔF/F peak of calcium signaling in LCNE neurons.

: Gabazine free base purchased from MedChemExpress. Usage Cited in: Elife. 2024 May 29.; The effects of intra-LC injection of Gabazine (4 μg/mL)and intra-VLPO injection of prazosin on the recovery time of midazolam. Microinjection of Gabazine into the LC could reduce the recovery time.

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製品説明

Gabazine is a selective and competitive antagonist of GABA_A receptor, with an IC₅₀ of 0.2 μM for GABA receptor^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	349 nM Compound: 2, SR95531	Antagonist activity at human recombinant GABA A receptor alpha1beta2gamma2S expressed in HEK293 cells assessed as inhibition of GABA-induced current by patch clamp electrophysiology Antagonist activity at human recombinant GABA A receptor alpha1beta2gamma2S expressed in HEK293 cells assessed as inhibition of GABA-induced current by patch clamp electrophysiology	[PMID: 21664131]
IMR-32	IC₅₀	7.38 μM Compound: SR 95531	Antagonist activity against GABA type-A receptor in human IMR32 cells assessed as GABA-induced response preincubated for 10 mins followed by GABA addition measured at 140 mins by Epic DMR assay Antagonist activity against GABA type-A receptor in human IMR32 cells assessed as GABA-induced response preincubated for 10 mins followed by GABA addition measured at 140 mins by Epic DMR assay	10.1039/C5MD00442J

分子量

287.31

分子式

C₁₅H₁₇N₃O₃

CAS 番号

105538-73-6

SMILES

O=C(CCCN1N=C(C2=CC=C(OC)C=C2)C=CC1=N)O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Ueno S,et al. Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor. J Neurosci. 1997 Jan 15;17(2):625-34. [Content Brief]

Gabazine free base Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gabazine105538-73-6SR95531SR 95531SR-95531GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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